Recombinant Human ATOX1 Protein, with Cu (I)

Cat.No. : ATOX1-225H
Product Overview : Recombinant full length Human Cu (I)-ATOX1 (aa 1-68) was expressed in E. coli. Binding of Cu (I) to the protein was confirmed by ICP.
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Description : This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
Source : E. coli
Species : Human
Form : In 20 mM Phosphate buffer pH 7.0.
Molecular Mass : 7.4 kDa
Protein length : aa 1-68
AA Sequence : MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LIATLKKTGK TVSYLGLE
Purity : >95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight < 10 kDa.
Notes : To avoid oxidation and leaking of the Cu(I) bound to the protein, keep and use the sample under inert atomosphere.
Storage : Store at - 20 centigrade. The protein is stable at 4 centigrade for at least 2 weeks and at 25 centigrade for at least several hours. After initial deforst, aliquot product into individual tubes under inert atomosphere and refreeze at - 20 centigrade. Avoid repeated freeze/defrost cycles. Avoid exposition to air.
Concentration : 1 mg/ml
Gene Name : ATOX1 ATX1 antioxidant protein 1 homolog (yeast) [ Homo sapiens ]
Official Symbol : ATOX1
Synonyms : ATOX1; ATX1 antioxidant protein 1 homolog (yeast); ATX1 (antioxidant protein 1, yeast) homolog 1; copper transport protein ATOX1; HAH1; metal transport protein ATX1; ATX1; MGC138453; MGC138455;
Gene ID : 475
mRNA Refseq : NM_004045
Protein Refseq : NP_004036
MIM : 602270
UniProt ID : O00244
Chromosome Location : 5q32
Pathway : Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem;
Function : copper chaperone activity; copper ion binding; copper-dependent protein binding; metal ion binding; metallochaperone activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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