Recombinant Human Carbonyl Reductase 3, His-tagged

• Cat.No.: CBR3-184H
• Product Overview: Recombinant human CBR3, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW =33 kDa (297aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Carbonyl reductase 3(CBR3)is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene – CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CBR3 carbonyl reductase 3 [ Homo sapiens ]
• Synonyms: CBR3; carbonyl reductase 3; hCBR3; SDR21C2; carbonyl reductase (NADPH) 3; NADPH-dependent carbonyl reductase 3; short chain dehydrogenase/reductase family 21C, member 2; EC 1.1.1.184; short chain dehydrogenase/reductase family 21C, member 2; SDR21C2; carbonyl reductase (NADPH) 3, EC 1.1.1.184
• Gene ID: 874
• mRNA Refseq: NM_001236
• Protein Refseq: NP_001227
• MIM: 603608
• UniProt ID: O75828
• Chromosome Location: 21q22.2
• Pathway: Arachidonic acid metabolism; Metabolic pathways
• Function: NADPH binding; binding; carbonyl reductase (NADPH) activity; oxidoreductase activity