Recombinant Human Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide, His-tagged

• Cat.No.: GNAZ-7159H
• Product Overview: Recombinant human GNAZ protein, fused to His-tag at N-terminus, was expressed in E. coli. MW: 43.0 kDa.

Specification

• Description: Guanine nucleotide-binding protein G(z) subunit alpha, also known as GNAZ, is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol.
• Molecular Mass: 43.0 kDa (375aa)
• Protein length: 1-355aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FSRSSEYHLE DNAAYYLNDL ERIAAADYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide [ Homo sapiens ]
• Official Symbol: GNAZ
• Synonyms: GNAZ; guanine nucleotide binding protein (G protein), alpha z polypeptide; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha; g(x) alpha chain; transducin alpha
• Gene ID: 2781
• mRNA Refseq: NM_002073
• Protein Refseq: NP_002064
• MIM: 139160
• UniProt ID: P19086
• Chromosome Location: 22q11.1-q11.2
• Pathway: Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; G-protein activation, organism-specific biosystem; G-protein mediated events, organism-specific biosystem
• Function: G-protein beta/gamma-subunit complex binding; G-protein coupled serotonin receptor binding; GTP binding; GTPase activity; guanyl nucleotide binding; guanyl-nucleotide exchange factor activity; metal ion binding; nucleotide binding; phosphatidylinositol phospholipase C activity; receptor signaling protein activity; signal transducer activity