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Recombinant Human Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide, His-tagged

Cat.No.: GNAZ-7159H
Product Overview: Recombinant human GNAZ protein, fused to His-tag at N-terminus, was expressed in E. coli. MW: 43.0 kDa.
Description: Guanine nucleotide-binding protein G(z) subunit alpha, also known as GNAZ, is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol.
Molecular Mass: 43.0 kDa (375aa)
Protein length: 1-355aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FSRSSEYHLE DNAAYYLNDL ERIAAADYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide [ Homo sapiens ]
Official Symbol: GNAZ
Synonyms: GNAZ; guanine nucleotide binding protein (G protein), alpha z polypeptide; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha; g(x) alpha chain; transducin alpha;
Gene ID: 2781
mRNA Refseq: NM_002073
Protein Refseq: NP_002064
MIM: 139160
UniProt ID: P19086
Chromosome Location: 22q11.1-q11.2
Pathway: Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; G-protein activation, organism-specific biosystem; G-protein mediated events, organism-specific biosystem;
Function: G-protein beta/gamma-subunit complex binding; G-protein coupled serotonin receptor binding; GTP binding; GTPase activity; guanyl nucleotide binding; guanyl-nucleotide exchange factor activity; metal ion binding; nucleotide binding; phosphatidylinositol phospholipase C activity; receptor signaling protein activity; signal transducer activity;

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