Active Recombinant Human PPIB

• Cat.No.: PPIB-8314H
• Product Overview: Cyclophilin B Human Recombinant produced in E.coli is a single, non-glycosylated,polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. PPIB is purified by chromatographic techniques.

Specification

• Description: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
• Source: E.coli
• Species: Human
• Form: 1 mg/ml solution containing 20 mM Tris 8.0, 20 mM NaCl, 0.5mM DTT and 10% glycerol.
• Bio-activity: Specific activity is 170 nmoles/min/ug, and is defined as the amount of enzyme that cleave 1umole of suc-AAFP-pNA per minute at 1C in Tris-Hcl pH8.0 using chymotrypsin.
• AA Sequence: MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEKGFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAGKDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE.
• Purity: Greater than 95.0% as determined by RP-HPLC and analysis by SDS-PAGE
• Notes: For research use only.
• Storage: PPIase Human Recombinant although stable at 4 ℃ for weeks, should be stored desiccated below -18 ℃. Please prevent freeze/thaw cycles.

Gene Information

• Gene Name: PPIB peptidylprolyl isomerase B (cyclophilin B) [ Homo sapiens ]
• Official Symbol: PPIB
• Synonyms: PPIB; peptidylprolyl isomerase B (cyclophilin B); peptidyl-prolyl cis-trans isomerase B; CYPB; OI9
• Gene ID: 5479
• mRNA Refseq: NM_000942
• Protein Refseq: NP_000933
• MIM: 123841
• UniProt ID: P23284
• Chromosome Location: 15q21-q22
• Pathway: Syndecan-1-mediated signaling events, organism-specific biosystem
• Function: isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding