"PPIB" Related Products

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Recombinant Human PPIB

Cat.No.: PPIB-8314H
Product Overview: Cyclophilin B Human Recombinant produced in E.coli is a single, non-glycosylated,polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. PPIB is purified by chromatographic techniques.
Description: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
Source: E.coli
Species: Human
Form: 1 mg/ml solution containing 20 mM Tris 8.0, 20 mM NaCl, 0.5mM DTT and 10% glycerol.
Bio-activity: Specific activity is 170 nmoles/min/ug, and is defined as the amount of enzyme that cleave 1umole of suc-AAFP-pNA per minute at 1C in Tris-Hcl pH8.0 using chymotrypsin.
AA Sequence: MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEKGFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAGKDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE.
Purity: Greater than 95.0% as determined by RP-HPLC and analysis by SDS-PAGE
Notes: For research use only.
Storage: PPIase Human Recombinant although stable at 4 ℃ for weeks, should be stored desiccated below -18 ℃. Please prevent freeze/thaw cycles.
Gene Name: PPIB peptidylprolyl isomerase B (cyclophilin B) [ Homo sapiens ]
Official Symbol: PPIB
Synonyms: PPIB; peptidylprolyl isomerase B (cyclophilin B); peptidyl-prolyl cis-trans isomerase B; CYPB; OI9;
Gene ID: 5479
mRNA Refseq: NM_000942
Protein Refseq: NP_000933
MIM: 123841
UniProt ID: P23284
Chromosome Location: 15q21-q22
Pathway: Syndecan-1-mediated signaling events, organism-specific biosystem;
Function: isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding;

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