Recombinant Human DHCR24, GST-tagged

• Cat.No.: DHCR24-11962H
• Product Overview: Recombinant Human DHCR24 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 217-516a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DHCR24 24-dehydrocholesterol reductase [ Homo sapiens ]
• Official Symbol: DHCR24
• Synonyms: DHCR24; 24-dehydrocholesterol reductase; delta(24)-sterol reductase; KIAA0018; seladin 1; diminuto/dwarf1 homolog; selective AD indicator 1; desmosterol-to-cholesterol enzyme; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; SELADIN1; Nbla03646; seladin-1
• Gene ID: 1718
• mRNA Refseq: NM_014762
• Protein Refseq: NP_055577
• MIM: 606418
• UniProt ID: Q15392
• Chromosome Location: 1p32.3
• Pathway: Cholesterol biosynthesis, organism-specific biosystem; Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol, organism-specific biosystem; Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: UDP-N-acetylmuramate dehydrogenase activity; delta24-sterol reductase activity; enzyme binding; flavin adenine dinucleotide binding; oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on the CH-CH group of donors, NA