Recombinant human TIMM8A, His-tagged
Cat.No. : | TIMM8A-2486H |
Product Overview : | Recombinant human TIMM8A proten, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | TIMM8A is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT |
Molecular Mass : | 13.4kDa (120aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMDSSSSS SAAGLGAVDP QLQHFIEVET QKQRFQQLVH QMTELCWEKC MDKPGPKLDS RAEACFVNCV ERFIDTSQFI LNRLEQTQKS KPVFSESLSD |
Purity : | >90 % by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Gene Name : | TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) [ Homo sapiens ] |
Official Symbol : | TIMM8A |
Synonyms : | TIMM8A; translocase of inner mitochondrial membrane 8 homolog A (yeast); DFN1, translocase of inner mitochondrial membrane 8 (yeast) homolog A; mitochondrial import inner membrane translocase subunit Tim8 A; DDP; MTS; deafness/dystonia peptide; deafness dystonia protein 1; X-linked deafness dystonia protein; DDP1; DFN1; TIM8; MGC12262; |
Gene ID : | 1678 |
mRNA Refseq : | NM_001145951 |
Protein Refseq : | NP_001139423 |
MIM : | 300356 |
UniProt ID : | O60220 |
Chromosome Location : | Xq22 |
Pathway : | Metabolism of proteins, organism-specific biosystem; Mitochondrial Protein Import, organism-specific biosystem; |
Function : | metal ion binding; |
Products Types
◆ Recombinant Protein | ||
TIMM8A-4534R | Recombinant Rhesus Macaque TIMM8A Protein, His (Fc)-Avi-tagged | +Inquiry |
TIMM8A-3239H | Recombinant Human TIMM8A, GST-tagged | +Inquiry |
TIMM8A-4720R | Recombinant Rhesus monkey TIMM8A Protein, His-tagged | +Inquiry |
TIMM8A-5603C | Recombinant Chicken TIMM8A | +Inquiry |
TIMM8A-1059Z | Recombinant Zebrafish TIMM8A | +Inquiry |
◆ Lysates | ||
TIMM8A-1065HCL | Recombinant Human TIMM8A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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