Recombinant Human PTPRC, StrepII-tagged
Cat.No. : | PTPRC-232H |
Product Overview : | Purified human recombinant receptor-type tyrosine-protein phosphatase C or CD45 protein (amino acids 598-1304, 707 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 81.5 kDa. (Accession NP_002829.2; UniProt P08575) |
- Specification
- Gene Information
- Related Products
Description : | This product is the intracellular domain of CD45, a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 598-1304, 707 a.a. |
AA Sequence : | KIYDLHKKRSCNLDEQQELVERDDE KQLMNVEPIHADILLETYKRKIADE GRLFLAEFQSIPRVFSKFPIKEARK PFNQNKNRYVDILPYDYNRVELSEI NGDAGSNYINASYIDGFKEPRKYIA AQGPRDETVDDFWRMIWEQKATVIV MVTRCEEGNRNKCAEYWPSMEEGTR AFGDVVVKINQHKRCPDYIIQKLNI VNKKEKATGREVTHIQFTSWPDHGV PEDPHLLLKLRRRVNAFSNFFSGPI VVHCSAGVGRTGTYIGIDAMLEGLE AENKVDVYGYVVKLRRQRCLMVQVE AQYILIHQALVEYNQFGETEVNLSE LHPYLHNMKKRDPPSEPSPLEAEFQ RLPSYRSWRTQHIGNQEENKSKNRN SNVIPYDYNRVPLKHELEMSKESEH DSDESSDDDSDSEEPSKYINASFIM SYWKPEVMIAAQGPLKETIGDFWQM IFQRKVKVIVMLTELKHGDQEICAQ YWGEGKQTYGDIEVDLKDTDKSSTY TLRVFELRHSKRKDSRTVYQYQYTN WSVEQLPAEPKELISMIQVVKQKLP QKNSSEGNKHHKSTPLLIHCRDGSQ QTGIFCALLNLLESAETEEVVDIFQ VVKALRKARPGMVSTFEQYQFLYDV IASTYPAQNGQVKKNNHQEDKIEFD NEVDKVKQDANCVNPLGAPEKLPEA KEQAEGSEPTSGTEGPEHSVNGPAS PALNQGS |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | PTPRC protein tyrosine phosphatase, receptor type, C [ Homo sapiens ] |
Official Symbol : | PTPRC |
Synonyms : | PTPRC; protein tyrosine phosphatase, receptor type, C; CD45; receptor-type tyrosine-protein phosphatase C; GP180; LCA; T200; CD45 antigen; T200 glycoprotein; leukocyte common antigen; leukocyte-common antigen; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; LY5; B220; L-CA; CD45R; |
Gene ID : | 5788 |
mRNA Refseq : | NM_002838 |
Protein Refseq : | NP_002829 |
MIM : | 151460 |
UniProt ID : | P08575 |
Chromosome Location : | 1q31-q32 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; |
Function : | hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity; |
Products Types
◆ Recombinant Protein | ||
PTPRC-1262H | Acitve Recombinant Human PTPRC protein(Met1-Lys416), hFc-tagged | +Inquiry |
PTPRC-133H | Active Recombinant Human PTPRC Protein, His-tagged | +Inquiry |
Ptprc-1203R | Recombinant Rat Ptprc Protein, His-tagged | +Inquiry |
Ptprc-550M | Active Recombinant Mouse Ptprc protein(Arg453-Ser1152) | +Inquiry |
PTPRC-686H | Recombinant Human PTPRC Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PTPRC-3045HCL | Recombinant Human PTPRC cell lysate | +Inquiry |
PTPRC-1141MCL | Recombinant Mouse PTPRC cell lysate | +Inquiry |
PTPRC-001MCL | Recombinant Mouse PTPRC cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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