Recombinant Human GART cell lysate

• Cat.No.: GART-687HCL

Specification

• Description: The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Homo sapiens ]
• Official Symbol: GART
• Synonyms: GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; PGFT, PRGS; trifunctional purine biosynthetic protein adenosine-3; AIRS; GARS; PAIS; PGFT; PRGS; GARTF; MGC47764
• Gene ID: 2618
• mRNA Refseq: NM_000819
• Protein Refseq: NP_000810
• MIM: 138440
• UniProt ID: P22102
• Chromosome Location: 21q22.11
• Pathway: 5-aminoimidazole ribonucleotide biosynthesis I, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine =>IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: ATP binding; ligase activity; metal ion binding; methyltransferase activity; nucleotide binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity; transferase activity