Active Recombinant Human SIK1 Protein, His-tagged

• Cat.No.: SIK1-431H
• Product Overview: Recombinant Human SIK1(1-303) fused with His tag was expressed in baculovirus infected Sf9 cells.

Specification

• Description: SIK is a protein kinase that is involved in regulating AMPK-related kinases. SIK may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Buffered aqueous glycerol solution
• Bio-activity: 296 nmol/min·mg
• Molecular Mass: ~36 kDa
• Quality Control Test: ≥80% (SDS-PAGE)
• Notes: After opening, aliquot into smaller quantities and store at -70 centigrade. Avoid repeating handling and multiple freeze/thaw cycles
• Storage: Store at -70 centigrade
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: SIK1 salt inducible kinase 1 [ Homo sapiens (human) ]
• Official Symbol: SIK1
• Synonyms: MSK; SIK; SIK-1; SNF1LK
• Gene ID: 150094
• mRNA Refseq: 173354
• Protein Refseq: NP_775490
• MIM: 605705
• UniProt ID: P57059
• Chromosome Location: 21q22.3