| Description : |
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
| Conjugation : |
Fc |
| Tissue specificity : |
Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is hig |
| Form : |
Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco |
| Purity : |
>95% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
| Storage : |
Store at +4°C. |
| Sequences of amino acids : |
Theoretical sequence: FSGSEATAAILSRAPWSLQSVNPGL KTNSSKEPKFTKC RSPERETFSCHWTDEVHHGTKNLGP IQLFYTRRNTQEW TQEWKECPDYVSAGENSCYFNSSFT SIWIPYCIKLTSN GGTVDEKCFSVDEIVQPDPPIALNW TLLNVSLTGIHAD IQVRWEAPRNADIQKGWMVLEYELQ YKEVNETKWKMMDPILTTSVPVYSL KVDKEYEVRVRSKQRNSGNYGEFSE VLY VTLPQMRIPKVDKKVEPKSCDKTHT CPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVV VDVSHEDPEVKFN WYVDGVEVHNAKTKPREEQYNSTYR VVSVLTVLHQDWL NGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSRDELTKNQVS LTCLVKGFYPSDIAVEWESNGQPEN NYK TTPPVLDSDGSFFLYSKLTVDKSRW QQGNVFSCSVMHE ALHNHYTQKSLSLSPGK |
| Sequence Similarities : |
Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain. |
