Recombinant Human GSG2

• Cat.No.: GSG2-29180TH
• Product Overview: Recombinant fragment of Human Haspin with N-terminal proprietary tag, 64kDa.

Specification

• Description: Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 Thr-3 during mitosis.
• Protein length: 329 amino acids
• Molecular Weight: 64.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferatin
• Biological activity: The Specific activity of GSG2-29180TH was determined to be 18 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: GSG2 germ cell associated 2 (haspin) [ Homo sapiens ]
• Official Symbol: GSG2
• Synonyms: GSG2; germ cell associated 2 (haspin); serine/threonine-protein kinase haspin; haspin
• Gene ID: 83903
• mRNA Refseq: NM_031965
• Protein Refseq: NP_114171
• MIM: 609240
• Uniprot ID: Q8TF76
• Chromosome Location: 17p13
• Function: ATP binding; DNA binding; histone kinase activity (H3-T3 specific); nucleotide binding; protein kinase activity