Recombinant Human KCNIP3, His-tagged

• Cat.No.: KCNIP3-26419TH
• Product Overview: Recombinant full length Human CSEN with N terminal His tag; 276 amino acids with tag, predicted MWt 31.4 kDa.

Specification

• Description: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
• Protein length: 256 amino acids
• Conjugation: HIS
• Molecular Weight: 31.400kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMQPAK EVTKASDGSLLGDLGHTPLSKKEGI KWQRPRLSRQALMRCCLVKWILSST APQGSDSSDSELELSTVRHQPEGLD QLQAQTKFTKKELQSLYRGFKNECP TGLVDEDTFKLIYAQFFPQGDATTY AHFLFNAFDADGNGAIHFEDFVVGL SILLRGTVHEKLKWAFNLYDINKDG YITKEEMLAIMKSIYDMMGRHTYPI LREDAPAEHVERFFEKMDRNQDGVV TIEEFLEACQKDENIMSSMQLFENV I
• Sequence Similarities: Belongs to the recoverin family.Contains 4 EF-hand domains.

Gene Information

• Gene Name: KCNIP3 Kv channel interacting protein 3, calsenilin [ Homo sapiens ]
• Official Symbol: KCNIP3
• Synonyms: KCNIP3; Kv channel interacting protein 3, calsenilin; calsenilin, presenilin binding protein, EF hand transcription factor , CSEN; calsenilin; DREAM; KCHIP3
• Gene ID: 30818
• mRNA Refseq: NM_001034914
• Protein Refseq: NP_001030086
• MIM: 604662
• Uniprot ID: Q9Y2W7
• Chromosome Location: 2q21.1
• Pathway: IL-3 Signaling Pathway, organism-specific biosystem
• Function: DNA binding; calcium ion binding; calcium-dependent protein binding; potassium channel activity; protein C-terminus binding