Recombinant Human NVL, His-tagged

• Cat.No.: NVL-30495TH
• Product Overview: Recombinant fragment, corresponding to amino acids 431-734 of Human NVL with an N terminal His tag. Predicted mwt: 34 kDa

Specification

• Description: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
• Form: Lyophilised:Reconstitute with 60 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: DQDPLSEEQMQGLCIELNDFIVALS SVQPSAKREGFVTVP NVTWADIGALEDIREELTMAILAPV RNPDQFKALGLVT PAGVLLAGPPGCGKTLLAKAVANES GLNFISVKGPELLNMYVGESERAVR QVFQRAKNSAPCVIFFDEVDALCPR RSD RETGASVRVVNQLLTEMDGLEARQQ VFIMAATNRPDII DPAILRPGRLDKTLFVGLPPPADRL AILKTITKNGTKPPL DADVNLEAIAGDLRCDCYTGADLSA LVREASICALRQE MARQKSGNEKGELKVSHKHFEEAFK KVRSSIS
• Sequence Similarities: Belongs to the AAA ATPase family.

Gene Information

• Gene Name: NVL nuclear VCP-like [ Homo sapiens ]
• Official Symbol: NVL
• Synonyms: NVL; nuclear VCP-like; nuclear valosin-containing protein-like; Nuclear valosin containing protein like; nuclear VCP like protein
• Gene ID: 4931
• mRNA Refseq: NM_001243146
• Protein Refseq: NP_001230075
• MIM: 602426
• Uniprot ID: O15381
• Chromosome Location: 1q41-q42.2
• Pathway: Ribosome biogenesis in eukaryotes, organism-specific biosystem; Ribosome biogenesis in eukaryotes, conserved biosystem
• Function: ATP binding; nucleoside-triphosphatase activity; nucleotide binding