Recombinant Human PPIB

• Cat.No.: PPIB-26338TH
• Product Overview: Recombinant Full Length Human Cyclophilin B produced in Saccharomyces cerevisiae; 216 amino acids, MWt 20.3 kDa. Protein is tagged with 26 kDa proprietary tag.

Specification

• Description: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MLRLSERNMK VLLAAALIAG SVFFLLLPGP SAADEKKKGP KVTVKVYFDL RIGDEDVGRV IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR KVESTKTDSR DKPLKDVIIA
• Sequence Similarities: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.Contains 1 PPIase cyclophilin-type domain.

Gene Information

• Gene Name: PPIB peptidylprolyl isomerase B (cyclophilin B) [ Homo sapiens ]
• Official Symbol: PPIB
• Synonyms: PPIB; peptidylprolyl isomerase B (cyclophilin B); peptidyl-prolyl cis-trans isomerase B; CYPB; OI9
• Gene ID: 5479
• mRNA Refseq: NM_000942
• Protein Refseq: NP_000933
• MIM: 123841
• Uniprot ID: P23284
• Chromosome Location: 15q21-q22
• Pathway: Syndecan-1-mediated signaling events, organism-specific biosystem
• Function: isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding