"RRM2" Related Products

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Recombinant Human RRM2, His-tagged

Cat.No.: RRM2-29474TH
Product Overview: Recombinant full-length Human RRM2 with a N terminal His-tag, 409 amino aicds with tag, predicted MWt 47kDa inclusive of tag.
Description: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
Protein length: 389 amino acids
Conjugation: HIS
Molecular Weight: 47.000kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDEPLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRGLMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF
Sequence Similarities: Belongs to the ribonucleoside diphosphate reductase small chain family.
Gene Name: RRM2 ribonucleotide reductase M2 [ Homo sapiens ]
Official Symbol: RRM2
Synonyms: RRM2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; ribonucleoside-diphosphate reductase subunit M2;
Gene ID: 6241
mRNA Refseq: NM_001034
Protein Refseq: NP_001025
MIM: 180390
Uniprot ID: P31350
Chromosome Location: 2p25-p24
Pathway: Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem;
Function: oxidoreductase activity; ribonucleoside-diphosphate reductase activity; ribonucleoside-diphosphate reductase activity; transition metal ion binding;

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