Recombinant Human SUV420H2

• Cat.No.: SUV420H2-27744TH
• Product Overview: Recombinant fragment, corresponding to amino acids 2-280 of Human KMT5C/SUV4-20h2 with N-terminal proprietary tag, 58kDa.

Specification

• Description: SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al.
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: SUV420H2 suppressor of variegation 4-20 homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: SUV420H2
• Synonyms: SUV420H2; suppressor of variegation 4-20 homolog 2 (Drosophila); histone-lysine N-methyltransferase SUV420H2; KMT5C; MGC2705
• Gene ID: 84787
• mRNA Refseq: NM_032701
• Protein Refseq: NP_116090
• MIM: 613198
• Uniprot ID: Q86Y97
• Chromosome Location: 19q13.42
• Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem
• Function: histone methyltransferase activity (H4-K20 specific); methyltransferase activity; protein binding; transferase activity