"PMM2" Related Products

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Recombinant Human Phosphomannomutase 2, His-tagged

Cat. No.: PMM2-2822H
Product Overview: Recombinant humanPMM2 protein,fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 30.2 kDa (266aa), confirmed by MALDI-TOF.
Description: PMM2, also known asPhosphomannomutase 2, belongs to the eukaryotic PMM family. PMM2 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. It catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mutations in PMM2 are associated with Congenital disorders of glycosylation (CDG)-Ia, an autosomal recessive disorder characterized by central nervous system dysfunction and multiorgan failure.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI CELLFS
Purity: > 95% by SDS – PAGE.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT, 0.1M NaCl.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PMM2 phosphomannomutase 2 [ Homo sapiens ]
Synonyms: PMM2; phosphomannomutase 2; CDG1; CDGS; CDG1a; PMM 2; EC 5.4.2.8; CDG1A
Gene ID: 5373
mRNA Refseq: NM_000303
Protein Refseq: NP_000294
MIM: 601785
UniProt ID: O15305
Chromosome Location: 16p13
Pathway: Amino sugar and nucleotide sugar metabolism; Fructose and mannose metabolism; Metabolic pathways
Function: isomerase activity; phosphomannomutase activity

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