Recombinant Human ANKFY1 Protein (A2-S1169), His/Strep tagged

• Cat.No.: ANKFY1-0882H
• Product Overview: Recombinant Human 8His-StrepII-TEV-(GG)-ANKFY1(A2-S1169 end) Protein was expressed in Insect cell.

Specification

• Description: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
• Source: Insect cell
• Species: Human
• Tag: His/Strep
• Form: Liquid
• Protein Length: A2-S1169
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ANKFY1 ankyrin repeat and FYVE domain containing 1 [ Homo sapiens (human) ]
• Official Symbol: ANKFY1
• Synonyms: ANKFY1; ankyrin repeat and FYVE domain containing 1; ankyrin repeat and FYVE domain-containing protein 1; ANKHZN; KIAA1255; ZFYVE14; Rabankyrin-5; ankyrin repeat hooked to zinc finger motif; ankyrin repeats hooked to a zinc finger motif; DKFZp686M19106
• Gene ID: 51479
• mRNA Refseq: NM_001257999
• Protein Refseq: NP_001244928
• MIM: 607927
• UniProt ID: Q9P2R3