Recombinant Human CDK19/CCNC/MED12 Protein (M1-Y502/M1-S283/M1-D100), GST/Flag/His-tagged
Cat.No. : | CDK19/CCNC/MED12-1659H |
Product Overview : | Recombinant Human N-GST-3C-CDK19(1-502end)/pFastBac1-N-Flag-6His-TEV-Cyclin C(1-283end)/pFastBac1(kozak)-MED12(M1-D100)-TEV protein with a GST/Flag/His was expressed in Insect cell |
- Specification
- Gene Information
- Related Products
Description : | Cyclin-dependent kinase 19, CDC2-related protein kinase 6, Cell division cycle 2-like protein kinase 6, Cell division protein kinase 19, Cyclin-dependent kinase 11, Death-preventing kinase; Cyclin-C, SRB11 homolog, hSRB11; Mediator of RNA polymerase II transcription subunit 12, Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45, Mediator complex subunit 12, OPA-containing protein, Thyroid hormone receptor-associated protein complex 230 kDa component, Trap230, Trinucleotide repeat-containing gene 11 protein Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
Source : | Insect cell |
Species : | Human |
Tag : | GST/Flag/His |
Form : | Liquid |
Protein Length : | M1-Y502/M1-S283/M1-D100 |
Endotoxin : | < 0.01 EU/μg of the protein |
Purity : | 80% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM HEPES (pH 7.5), 150 mM NaCl, 5% glycerol. |
Shipping : | It is shipped out with blue ice. |
Gene Name : | CDK19 cyclin-dependent kinase 19 [ Homo sapiens (human) ] |
Official Symbol : | CDK19 |
Synonyms : | Cyclin-dependent kinase 19; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein |
Gene ID : | 23097 |
mRNA Refseq : | NM_015076 |
Protein Refseq : | NP_055891 |
MIM : | 614720 |
UniProt ID : | Q9BWU1 |
Products Types
◆ Recombinant Protein | ||
CDK19/CCNC/MED12-1658H | Recombinant Human CDK19/CCNC/MED12 Protein (M1-Y502/M1-S283/M1-D100) | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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