Recombinant Human CIAO1 Protein (M1-L339), His/Strep tagged

• Cat.No.: CIAO1-0616H
• Product Overview: Recombinant Human 6His-strepII-TEV-GG-CIAO1(M1-L339 end) Protein was expressed in E. coli.

Specification

• Description: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
• Source: E. coli
• Species: Human
• Tag: His/Strep
• Form: Liquid
• Protein Length: M1-L339
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: CIAO1 cytosolic iron-sulfur protein assembly 1 [ Homo sapiens (human) ]
• Official Symbol: CIAO1
• Synonyms: CIAO1; cytosolic iron-sulfur protein assembly 1; cytosolic iron sulfur protein assembly 1 homolog (S. cerevisiae), WD repeat domain 39, WDR39; probable cytosolic iron-sulfur protein assembly protein CIAO1; CIA1; WD40 protein Ciao1; WD repeat domain 39; WD repeat-containing protein 39; cytosolic iron-sulfur protein assembly 1 homolog; WDR39
• Gene ID: 9391
• mRNA Refseq: NM_004804
• Protein Refseq: NP_004795
• MIM: 604333
• UniProt ID: O76071