Recombinant Human GABRA5(M1-K346, 1-31, signal peptide, SQPARAA, K424-K462 end)-10His and 8His-GST-TEV-GG-MUSK(R519-V869 end) Protein
| Cat.No. : | GABRA5/MUSK-25H |
| Product Overview : | Recombinant human GABRA5(M1-K346) (1-31, signal peptide)-(SQPARAA)-GABRA5(K424-K462 end)-10His/8His-GST-TEV-GG-MUSK(R519-V869 end) was expressed in mammalian cells. |
- Specification
- Gene Information
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| Description : | Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation. |
| Source : | Mammalian cell |
| Species : | Human |
| Tag : | GABRA5: C-10His MUSK: N-8×His-GST |
| Form : | Liquid |
| Protein Length : | GABRA5: M1-K346, 1-31, signal peptide, SQPARAA, K424-K462 end MUSK: R519-V869 end |
| Endotoxin : | < 0.01 EU/μg of the protein |
| Purity : | 50% |
| Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade |
| Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : | 20 mM HEPES (pH 7.5), 150 mM NaCl, 0.005% GDN, 0.0005% CHS |
| Shipping : | It is shipped out with blue ice. |
| Official Symbol : | GABRA5/MUSK |
| Synonyms : | GABRA5/MUSK; GABRA5; MUSK |
| UniProt ID : | P31644; O15146 |
| Official Symbol : | GABRA5/MUSK |
| Synonyms : | GABRA5/MUSK; GABRA5; MUSK |
| UniProt ID : | P31644; O15146 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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