Recombinant Human OTUD7B Protein (T2-F843), His/Strep tagged

• Cat.No.: OTUD7B-0722H
• Product Overview: Recombinant Human 8His-StrepII-TEV-(GG)-OTUD7B(T2-F843 end) Protein was expressed in Insect cell.

Specification

• Description: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin.
• Source: Insect cell
• Species: Human
• Tag: His/Strep
• Form: Liquid
• Protein Length: T2-F843
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: OTUD7B OTU domain containing 7B [ Homo sapiens (human) ]
• Official Symbol: OTUD7B
• Synonyms: OTUD7B; OTU domain containing 7B; ZA20D1, zinc finger, A20 domain containing 1; OTU domain-containing protein 7B; CEZANNE; zinc finger protein Cezanne; zinc finger, A20 domain containing 1; cellular zinc finger anti-NF-kappaB Cezanne; zinc finger A20 domain-containing protein 1; cellular zinc finger anti-NF-kappa-B protein; ZA20D1
• Gene ID: 56957
• mRNA Refseq: NM_020205
• Protein Refseq: NP_064590
• MIM: 611748
• UniProt ID: Q6GQQ9