Recombinant Human PPIA

• Cat.No.: PPIA-26337TH
• Product Overview: Recombinant Full Length Human Cyclophilin A produced in Saccharomyces cerevisiae; amino acids 1-165; 165 amino acids, 18kDa.

Specification

• Description: This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
• Sequence Similarities: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.Contains 1 PPIase cyclophilin-type domain.

Gene Information

• Gene Name: PPIA peptidylprolyl isomerase A (cyclophilin A) [ Homo sapiens ]
• Official Symbol: PPIA
• Synonyms: PPIA; peptidylprolyl isomerase A (cyclophilin A); peptidyl-prolyl cis-trans isomerase A; CYPA
• Gene ID: 5478
• mRNA Refseq: NM_021130
• Protein Refseq: NP_066953
• MIM: 123840
• Uniprot ID: P62937
• Chromosome Location: 7p13
• Pathway: APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem; Basigin interactions, organism-specific biosystem; Binding and entry of HIV virion, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Early Phase of HIV Life Cycle, organism-specific biosystem
• Function: isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding