Recombinant Human RRM2B Protein, MYC/DDK-tagged

• Cat.No.: RRM2B-1963H
• Product Overview: Recombinant human RRM2B protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RRM2B ribonucleotide reductase M2 B (TP53 inducible) [ Homo sapiens ]
• Official Symbol: RRM2B
• Synonyms: MTDPS8A; MTDPS8B; P53R2
• Gene ID: 50484
• mRNA Refseq: NM_001172477
• Protein Refseq: NP_001165948
• MIM: 604712
• UniProt ID: Q7LG56