| Description : |
Summary:This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
143.2 kDa |
| AA Sequence : |
MQCLAAALKDETNMSGGGEQADILP ANYVVKDRWKVLKKIGGGGFGEIYE AMDLLTRENVALKVESAQQPKQVLK MEVAVLKKLQGKDHVCRFIGCGRNE KFNYVVMQLQGRNLADLRRSQPRGT FTLSTTLRLGKQILESIEAIHSVGF LHRDIKPSNFAMGRLPSTYRKCYML DFGLARQYTNTTGDVRPPRNVAGFR GTVRYASVNAHKNREMGRHDDLWSL FYMLVEFAVGQLPWRKIKDKEQVGM IKEKYEHRMLLKHMPSEFHLFLDHI ASLDYFTKPDYQLIMSVFENSMKER GIAENEAFDWEKAGTDALLSTSTST PPQQNTRQTAAMFGVVNVTPVPGDL LRENTEDVLQGEHLSDQENAPPILP GRPSEGLGPSPHLVPHPGGPEAEVW EETDVNRNKLRINIGKSPCVEEEQS RGMGVPSSPVRAPPDSPTTPVRSLR YRRVNSPESERLSTADGRVELPERR SRMDLPGSPSRQACSSQPAQMLSVD TGHADRQASGRMDVSASVEQEALSN AFRSVPLAEEEDFDSKEWVIIDKET ELKDFPPGAEPSTSGTTDEEPEELR PLPEEGEERRRLGAEPTVRPRGRSM QALAEEDLQHLPPQPLPPQLSQGDG RSETSQPPTPGSPSHSPLHSGPRPR RRESDPTGPQRQVFSVAPPFEVNGL PRAVPLSLPYQDFKRDLSDYRERAR LLNRVRRVGFSHMLLTTPQVPLAPV QPQANGKEEEEEEEEDEEEEEEDEE EEEEEEEEEEEEEEEEEEEEEAAAA VALGEVLGPRSGSSSEGSERSTDRS QEGAPSTLLADDQKESRGRASMADG DLEPEEGSKTLVLVSPGDMKKSPVT AELAPDPDLGTLAALTPQHERPQPT GSQLDVSEPGTLSSVLKSEPKPPGP GAGLGAGTVTTGVGGVAVTSSPFTK VERTFVHIAEKTHLNVMSSGGQALR SEEFSAGGELGLELASDGGAVEEGA RAPLENGLALSGLNGAEIEGSALSG APRETPSEMATNSLPNGPALADGPA PVSPLEPSPEKVATISPRRHAMPGS RPRSRIPVLLSEEDTGSEPSGSLSA KERWSKRARPQQDLARLVMEKRQGR LLLRLASGASSSSSEEQRRASETLS GTGSEEDTPASEPAAALPRKSGRAA ATRSRIPRPIGLRMPMPVAAQQPAS RSHGAAPALDTAITSRLQLQTPPGS ATAADLRPKQPPGRGLGPGRAQAGA RPPAPRSPRLPASTSAARNASASPR SQSLSRRESPSPSHQARPGVPPPRG VPPARAQPDGTPSPGGSKKGPRGKL QAQRATTKGRAGGAEGRAGARTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
