Recombinant Mouse Ccnh Protein, Myc/DDK-tagged

• Cat.No.: Ccnh-2048M
• Product Overview: Purified recombinant protein of mouse full-length cyclin H (Ccnh), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 37.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ccnh cyclin H [ Mus musculus (house mouse) ]
• Official Symbol: Ccnh
• Synonyms: Ccnh; cyclin H; AI661354; AV102684; AW538719; 6330408H09Rik; cyclin-H
• Gene ID: 66671
• mRNA Refseq: NM_023243
• Protein Refseq: NP_075732
• UniProt ID: Q61458