Recombinant Mouse Cers6 Protein, Myc/DDK-tagged

• Cat.No.: Cers6-2124M
• Product Overview: Purified recombinant protein of mouse full-length ceramide synthase 6 (Cers6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor. Can use other acyl donors, but with less efficiency. Ceramides generated by CERS6 play a role in inflammatory response. Acts as a regulator of metabolism and hepatic lipid accumulation. Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 44.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cers6 ceramide synthase 6 [ Mus musculus (house mouse) ]
• Official Symbol: Cers6
• Synonyms: Cers6; ceramide synthase 6; L; T1; Cer; T1L; Lass6; AW544719; 4732462C07Rik; ceramide synthase 6; LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; longevity assurance homolog 6
• Gene ID: 241447
• mRNA Refseq: NM_172856
• Protein Refseq: NP_766444
• UniProt ID: Q8C172