Recombinant Mouse Nsfl1c Protein, Myc/DDK-tagged

• Cat.No.: Nsfl1c-4507M
• Product Overview: Purified recombinant protein of mouse full-length NSFL1 (p97) cofactor (p47) (Nsfl1c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 41 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nsfl1c NSFL1 (p97) cofactor (p47) [ Mus musculus (house mouse) ]
• Official Symbol: Nsfl1c
• Synonyms: NSFL1C; NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; p97 cofactor p47; p47; Stxbp3a; Munc-18c; MGC61403; MGC86097
• Gene ID: 386649
• mRNA Refseq: NM_198326
• Protein Refseq: NP_938085
• UniProt ID: Q9CZ44