Active Recombinant Full Length Human ATR and ATRIP co-expressed Protein, Flag,cMyc-tagged
| Cat.No. : | ATR-ATRIP-22HFL |
| Product Overview : | Recombinant, human FLAG-tagged ATR full length (GenBank NM_001184.3*) and recombinant, human cMyctagged ATRIP full length, (GenBank AF451323.1) co-expressed in a mammalian cell line. |
- Specification
- Gene Information
- Related Products
| Description : | Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. |
| Source : | mammalian cell line |
| Species : | Human |
| Tag : | Flag,cMyc |
| Protein length : | Full Length |
| Form : | 0.13mg/ml of enzyme in storage buffer. |
| Bio-activity : | This lot of ATR/ATRIP, active is active when tested using full length, recombinant p53 as the substrate, and meets product specifications. |
| Molecular Mass : | ATR 303 kDa, ATRIP 87 kDa |
| Purity : | Purity 50% by SDS-PAGE and Coomassie blue staining. |
| Applications : | Drug Discovery & Development |
| Storage : | 1 year at -70 centigrade. |
| Handling Advice : | Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade. |
| Use/Stability : | On receipt of material store at -20 centigrade. Unopened reagent is stable for a minimum of 6 months from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing the cap. |
| Gene Name : | ATR ATR serine/threonine kinase [ Homo sapiens (human) ] and ATRIP ATR interacting protein [ Homo sapiens (human) ] |
| Official Symbol : | ATR and ATRIP |
| Synonyms : | ATR and ATRIP; ATR serine/threonine kinase and ATR interacting protein; FRP1; MEC1; SCKL; FCTCS; SCKL1 |
| Gene ID : | 545 and 84126 |
| mRNA Refseq : | NM_001184.4 and NM_130384.3 |
| Protein Refseq : | NP_001175.2 and NP_569055.1 |
| MIM : | 601215 and 606605 |
| UniProt ID : | Q13535 and Q8WXE1 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket
