"PMM1" Related Products

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Recombinant Human Phosphomannomutase 1, His-tagged

Cat. No.: PMM1-803H
Product Overview: Recombinant human PMM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 31.9kDa (282aa).
Description: PMM1 (Phosphomannomutase 1) is an enzyme that involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. This enzyme catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. In addition, it may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAVTAQAARR KERVLCLFDV DGTLTPARQK IDPEVAAFLQ KLRSRVQIGV VGGSDYCKIA EQLGDGDEVI EKFDYVFAEN GTVQYKHGRL LSKQTIQNHL GEELLQDLIN FCLSYMALLR LPKKRGTFIE FRNGMLNISP IGRSCTLEER IEFSELDKKE KIREKFVEAL KTEFAGKGLR FSRGGMISFD VFPEGWDKRY CLDSLDQDSF DTIHFFGNET SPGGNDFEIF ADPRTVGHSV VSPQDTVQRC REIFFPETAH EA
Formulation: Liquid, 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 100mM Nacl, 0.1mM PMSF
Purity: > 90% by SDS - PAGE
Concentration: 0.5mg/ml (determined by Bradford assay)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PMM1 phosphomannomutase 1 [Homo sapiens]
Synonyms: Phosphomannomutase 1; PMM1; PMMH-22; brain glucose-1,6-bisphosphatase; sec53; EC 5.4.2.8; PMMH-22; PMMH22;OTTHUMP00000028766
Gene ID: 5372
mRNA Refseq: NM_002676
Protein Refseq: NP_002667
MIM: 601786
UniProt ID: Q92871
Chromosome Location: 22q13.2
Function: isomerase activity; metal ion binding; phosphomannomutase activity

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