Recombinant Human Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, His-tagged

• Cat.No.: SERPINE1-5116H
• Product Overview: Recombinant human SERPINE1, fused to His tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: SERPINE1-5116H
• Description: Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) super family. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, the activators of plasminogen and hence fibrinolysis. PAI-1 is mainly produced by the endothelium but is also secreted by other tissue types, such as adipose tissue.
• Concentration: 1 mg/ml
• Source: Human
• Host: E.coli
• Form: Supplied as a liquid in 150mM Na2HPO4, pH 6.6, containing 0.5mM NaCl, 2mM Glutathione, and 0.01% Tween-80.
• Purity: > 95% by SDS - PAGE
• Sequence: 24-402 amino acids: MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSD
• Molecular Mass: 45 kDa (400 aa)
• Applications: SDS-PAGE
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [ Homo sapiens ]
• Official Symbol: SERPINE1
• Synonyms: Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; PAIE; Clade E; PLANH1; SERPINE 1; SERPINE1; PAI; PAI-1; PAI1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inhibitor-1; plasminogen activator inhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• UniProt ID: P05121
• Chromosome Location: 7q21.3-q22
• Pathway: Adipogenesis; Blood Clotting Cascade; Chagas disease (American trypanosomiasis); Circadian Clock; Complement and Coagulation Cascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2F transcription factor network; Formation of Platelet plug; HIF-1-alpha transcription factor network; HIF-2-alpha transcription factor network; Hemostasis; Platelet Activation; Platelet degranulation; Regulation of nuclear SMAD2/3 signaling
• Function: peptidase inhibitor activity; protease binding; protein binding; serine-type endopeptidase activity; contributes_to receptor binding