SERPINE1
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Official Full Name
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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Overview
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] -
Synonyms
SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Canine
- Cynomolgus Monkey
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293T
- Human
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse Plasma
- Rabbit
- Rabbit Plasma
- Rat Plasma
- Yeast
- C
- His
- Cys
- Fluorescein
- GST
- hFc
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- NBD
- N
- Non
- LRP
- Involved Pathway
- Protein Function
- Interacting Protein
- SERPINE1 Related Articles
- SERPINE1 Related Research Area
SERPINE1 involved in several pathways and played different roles in them. We selected most pathways SERPINE1 participated on our site, such as HIF- signaling pathway, p signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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HIF- signaling pathway | INSR;PFKL;SLC2A1;EIF4E2;CUL2;PDK1;PRKCA;ENO2;AKT2 |
p signaling pathway | ZMAT3;CCNB3;CD82B;BBC3;SIAH1;COP1;GTSE1;PTEN;PTENB |
Hippo signaling pathway | FZD6;LLGL2;SMAD1;PPP1CB;BTRC;WNT16;WNT6;ITGB2;PRKCI |
Complement and coagulation cascades | FGB;C8B;MBL1;CD59A;PLG;F12;KLKB1;CFB;SERPINA5 |
Chagas disease (American trypanosomiasis) | LOC100033925;IL12B;AKT1;PPP2R1A;TGFBR1;PIK3R3;SMAD3;BDKRB2;MAPK13 |
SERPINE1 has several biochemical functions, for example, protease binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINE1 itself. We selected most functions SERPINE1 had, and list some proteins which have the same functions with SERPINE1. You can find most of the proteins on our site.
Function | Related Protein |
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protease binding | TNFAIP3;CRADD;OS9;ADAMTSL4;RNF139;SERPINA1;PEO1;CFLAR;BDKRB2 |
protein binding | VHL;PNKD;C1orf35;PVRL4;NMI;DDX47;MAGEA1;FOXD3;RNF216 |
receptor binding | Ifnl2;LIF;AMH;HLA-B;ARPP19A;MLN;TNFSF13;ANXA1;MAG |
serine-type endopeptidase inhibitor activity | MUG2;OVST;SPINT2;WFDC6B;WFDC10A;EPPIN;PTI;APPA;SERPINA5 |
SERPINE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINE1.
SGTA; SGTB; UBQLN1; UBQLN1; ORM1; PLAU; PLAT; VTN; UBQLN4
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.
Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.
SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.
The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.
In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.
In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.
Customer Reviews (3)
Write a reviewIt has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
When used for experiments, the experimental conditions and results are highly repeatable.
SERPINE1 has good solubility and is easy to operate and purify.
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