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SERPINE1

  • Official Full Name

    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

  • Overview

    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Synonyms

    SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Cynomolgus Monkey
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse Plasma
  • Rabbit
  • Rabbit Plasma
  • Rat Plasma
  • Yeast
  • C
  • His
  • Cys
  • Fluorescein
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • NBD
  • N
  • Non
  • LRP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SERPINE1-5506H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, His-tagged E.coli His
Human SERPINE1-5117H Recombinant Human Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Human N/A
Human SERPINE1-5490H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 Insect Cell N/A
Human SERPINE1-5509H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Human SERPINE1-5116H Recombinant Human Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, His-tagged Human His
Human SERPINE1-1848H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Human SERPINE1-5511H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Human SERPINE1-5488H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Human SERPINE1-5492H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, NBD-tagged E.coli NBD
Human SERPINE1-5493H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Cys-tagged E.coli Cys
Human SERPINE1-5497H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Cys-tagged E.coli Cys
Human SERPINE1-5502H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Fluorescein-tagged E.coli Fluorescein
Human SERPINE1-5496H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Non-LRP-tagged E.coli Non-LRP
Human SERPINE1-5494H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Cys-tagged E.coli Cys
Human SERPINE1-5499H Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Cys-tagged E.coli Cys
Human SERPINE1-2600H Recombinant Human SERPINE1, GST-tagged E.coli GST 1-402aa
Human SERPINE1-29521TH Recombinant Human SERPINE1 E.coli N/A
Human SERPINE1-30721TH Recombinant Human SERPINE1 E.coli N/A
Human SERPINE1-30724TH Recombinant Human SERPINE1 E.coli N/A
Human SERPINE1-2751H Recombinant Human SERPINE1 protein, His-tagged E.coli His His25~Pro402 (Accession # P05121)
Human SERPINE1-28262TH Recombinant Human SERPINE1 N/A
Human SERPINE1-535H Recombinant Human SERPINE1, His-tagged E.coli His
Human SERPINE1-30728TH Recombinant Human SERPINE1 E.coli N/A
Human SERPINE1-2458H Recombinant Human SERPINE1, Active Form Insect Cell N/A
Human SERPINE1-3158H Recombinant Human SERPINE1, His tagged Human Cell His
Human SERPINE1-2383HCL Recombinant Human SERPINE1 cell lysate Human Cell N/A
Human CAB11601RH Rabbit Monoclonal Antibody to Human Serine Peptidase Inhibitor, Clade E, Member 1 Rabbit N/A
Human SERPINE1-1003H Recombinant Human SERPINE1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SERPINE1-122H Human Plasminogen Activator Inhibitor-1 (PAI-1), plasma Reference standard CHO N/A
Human SERPINE1-2400H Recombinant Human SERPINE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SERPINE1-5884H Recombinant Human SERPINE1 Protein (Gly21-Pro402), N-His tagged E.coli N-His Gly21-Pro402
Human SERPINE1-29522TH Native Human SERPINE1 E.coli N/A
Mouse Serpine1-2752M Recombinant Mouse Serpine1 protein, His & T7-tagged E.coli His/T7 Gln141~Pro389 (Accession # P22777)
Mouse Serpine1-5282M Recombinant Mouse Serine (or cysteine) Peptidase Inhibitor, Clade E, Member 1 Mouse Plasma N/A
Mouse Serpine1-5319M Recombinant Mouse Serine (or cysteine) Peptidase Inhibitor, Clade E, Member 1 E.coli N/A
Mouse Serpine1-2462M Recombinant Mouse Serpine1 E.coli N/A
Mouse Serpine1-3483M Recombinant Mouse Serpine1 protein, His-SUMO-tagged E.coli His-SUMO 23-402aa
Mouse Serpine1-100M Recombinant Mouse Serpine1 Protein, His-tagged HEK293 His
Mouse Serpine1-5516M Recombinant Mouse Serpine1 protein, His-tagged Yeast His 23-402aa
Mouse Serpine1-5790M Recombinant Mouse Serpine1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Serpine1-6802M Recombinant Mouse Serpine1 Protein (Leu24-Ser402), C-His tagged Mammalian cells C-His Leu24-Ser402
Rat Serpine1-564R Active Recombinant Rat Serpine1 protein, hFc-tagged HEK293 hFc Met1-Pro402
Rat Serpine1-2753R Recombinant Rat Serpine1 protein, His & T7-tagged E.coli His/T7 Ser24~Pro402 (Accession # P20961)
Rat Serpine1 -98R Recombinant Glycosylated Rat PAI-1 Stable Mutant Insect Cell N/A
Rat Serpine1-5310R Recombinant Rat Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 Rat Plasma N/A
Rat Serpine1 -81R Recombinant Rat PAI-1 wild type active fraction, His-tagged E.coli His
Rat Serpine1-5516R Recombinant Rat Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Rat SERPINE1-5344R Recombinant Rat SERPINE1 Protein Mammalian Cell His
Rat Serpine1-565R Recombinant Rat Serpine1, His-tagged Human Cell His Met1-Pro402
Rat SERPINE1-001RCL Recombinant Rat SERPINE1 cell lysate Human Cell N/A
Rat Serpine1-3484R Recombinant Rat Serpine1 protein, His-SUMO-tagged E.coli His-SUMO 24-402aa
Rat SERPINE1-5003R-B Recombinant Rat SERPINE1 Protein Pre-coupled Magnetic Beads HEK293
Rat SERPINE1-5003R Recombinant Rat SERPINE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit SERPINE1-5320R Recombinant Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Rabbit SERPINE1-5484R Recombinant Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Rabbit SERPINE1-1866R Recombinant Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 E.coli N/A
Rabbit SERPINE1-5514R Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 Rabbit Plasma N/A
Dog SERPINE1 -86D Recombinant Glycosylated canine (dog) PAI-1 Wild Type Latent Fraction Insect Cell N/A
Canine SERPINE1-90C Active Recombinant Canine SERPINE1 Insect Cell N/A
Canine SERPINE1-89C Active Recombinant Canine SERPINE1 Insect Cell N/A
Cynomolgus Monkey SERPINE1 -88C Recombinant Cyno Monkey PAI-1 wild type active fraction E.coli N/A
Cynomolgus Monkey SERPINE1 -89C Recombinant Cyno Monkey PAI-1 wild type latent fraction E.coli N/A
Zebrafish SERPINE1-6435Z Recombinant Zebrafish SERPINE1 Mammalian Cell His
Pig SERPINE1-87P Recombinant Porcine PAI-1 wild type active form E.coli N/A
Kit-0782 SERPINE1 (Human) Chromogenic Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SERPINE1 Related Articles
  • SERPINE1 Related Research Area

SERPINE1 involved in several pathways and played different roles in them. We selected most pathways SERPINE1 participated on our site, such as HIF- signaling pathway, p signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayINSR;PFKL;SLC2A1;EIF4E2;CUL2;PDK1;PRKCA;ENO2;AKT2
p signaling pathwayZMAT3;CCNB3;CD82B;BBC3;SIAH1;COP1;GTSE1;PTEN;PTENB
Hippo signaling pathwayFZD6;LLGL2;SMAD1;PPP1CB;BTRC;WNT16;WNT6;ITGB2;PRKCI
Complement and coagulation cascadesFGB;C8B;MBL1;CD59A;PLG;F12;KLKB1;CFB;SERPINA5
Chagas disease (American trypanosomiasis)LOC100033925;IL12B;AKT1;PPP2R1A;TGFBR1;PIK3R3;SMAD3;BDKRB2;MAPK13

SERPINE1 has several biochemical functions, for example, protease binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINE1 itself. We selected most functions SERPINE1 had, and list some proteins which have the same functions with SERPINE1. You can find most of the proteins on our site.

Function Related Protein
protease bindingTNFAIP3;CRADD;OS9;ADAMTSL4;RNF139;SERPINA1;PEO1;CFLAR;BDKRB2
protein bindingVHL;PNKD;C1orf35;PVRL4;NMI;DDX47;MAGEA1;FOXD3;RNF216
receptor bindingIfnl2;LIF;AMH;HLA-B;ARPP19A;MLN;TNFSF13;ANXA1;MAG
serine-type endopeptidase inhibitor activityMUG2;OVST;SPINT2;WFDC6B;WFDC10A;EPPIN;PTI;APPA;SERPINA5

SERPINE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINE1.

SGTA; SGTB; UBQLN1; UBQLN1; ORM1; PLAU; PLAT; VTN; UBQLN4

Yu, ZY; Lu, B; et al. Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:824-831(2015).
Dittmann, M; Hoffmann, HH; et al. A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation. CELL 160:631-643(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are there any gene polymorphisms or mutations in SERPINE1, and how do these mutations affect function? 11/13/2022

Yes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.

What are the potential therapeutic applications of SERPINE1 inhibitors or activators? 10/03/2022

Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.

How does SERPINE1 affect apoptosis and repair of nerve cells? 07/17/2022

SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.

What are the new directions or breakthroughs in the study of SERPINE1 and its related molecular mechanisms in future research? 02/18/2022

The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.

Are there other inhibitors or activators in the SERPINE1? 04/03/2021

In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.

How is SERPINE1 related to Alzheimer's disease? 09/07/2020

In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.

Customer Reviews (3)

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Reviews
06/02/2022

    It has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

    07/16/2021

      When used for experiments, the experimental conditions and results are highly repeatable.

      02/28/2021

        SERPINE1 has good solubility and is easy to operate and purify.

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