"IYD" Related Products

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Recombinant Human iodotyrosine deiodinase, His-tagged

Cat.No.: IYD-495H
Product Overview: IYD, 24-214aa Human, His tag, E.coli
Description: IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Molecular Mass: 25.1kDa (214aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSDRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: IYD?iodotyrosine deiodinase [?Homo sapiens?(human) ]
Official Symbol: IYD
Synonyms: IYD; TDH4; DEHAL1; C6orf71; dJ422F24.1; iodotyrosine deiodinase; iodotyrosine dehalogenase 1; IYD-1; NP_001158166.1; EC 1.22.1.1; NP_001158167.1; NP_981932.1
Gene ID: 389434
mRNA Refseq: NM_001164694
Protein Refseq: NP_001158166
MIM: 612025
UniProt ID: Q6PHW0
Chromosome Location: 6q25.1
Pathway: Amine-derived hormones; Metabolism of amino acids and derivatives; Thyroid hormone synthesis
Function: iodide peroxidase activity; oxidoreductase activity

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