Recombinant Human torsin family 1, member A (torsin A), His-tagged

• Cat.No.: TOR1A-536H
• Product Overview: TOR1A, 21-332aa, Human, His tag, E.coli

Specification

• Description: TOR1A is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. Recombinant human TOR1A protein, His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 38 kDa (333aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MVEPISLGLA LAGVLTGYIY PRLYCLFAEC CGQKRSLSRE ALQKDLDDNL FGQHLAKKII LNAVFGFINN PKPKKPLTLS LHGWTGTGKN FVSKIIAENI YEGGLNSDYV HLFVATLHFP HASNITLYKD QLQLWIRGNV SACARSIFIF DEMDKMHAGL IDAIKPFLDY YDLVDGVSYQ KAMFIFLSNA GAERITDVAL DFWRSGKQRE DIKLKDIEHA LSVSVFNNKN SGFWHSSLIH RNLIDYFVPF LPLEYKHLKM CIRVEMQSRG YEIDEDIVSR VAEEMTFFPK EERVFSDKGC KTVFTKLDYY YDD
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TOR1A torsin family 1, member A (torsin A) [ Homo sapiens ]
• Official Symbol: TOR1A
• Synonyms: TOR1A; torsin family 1, member A (torsin A); dystonia 1, torsion (autosomal dominant; torsin A) , DYT1; torsin-1A; DQ2; dystonia 1 protein; torsin family 1 member A; dystonia 1, torsion (autosomal dominant; torsin A); DYT1
• Gene ID: 1861
• mRNA Refseq: NM_000113
• Protein Refseq: NP_000104
• MIM: 605204
• UniProt ID: O14656
• Chromosome Location: 9q32-q34
• Pathway: Alpha-synuclein signaling, organism-specific biosystem
• Function: ATP binding; nucleotide binding; serine-type endopeptidase activity; unfolded protein binding