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Recombinant Human inhibitor of growth family, member 1, His-tagged

Cat.No.: ING1-668H
Product Overview: ING1, 1-279 aa Human, His tag, E.coli
Description: ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. This protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. Recombinant human ING1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Molecular Mass: 34.3 kDa (302aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMLSPANG EQLHLVNYVE DYLDSIESLP FDLQRNVSLM REIDAKYQEI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY NR
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 1mg/ml (determined by Bradford assay)
Gene Name: ING1 inhibitor of growth family, member 1 [ Homo sapiens ]
Official Symbol: ING1
Synonyms: ING1; inhibitor of growth family, member 1; inhibitor of growth protein 1; growth inhibitor ING1; growth inhibitory protein ING1; inhibitor of growth 1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a; tumor suppressor ING1;
Gene ID: 3621
mRNA Refseq: NM_005537
Protein Refseq: NP_005528
MIM: 601566
UniProt ID: Q9UK53
Chromosome Location: 13q34
Pathway: Senescence and Autophagy, organism-specific biosystem;
Function: metal ion binding; methylated histone residue binding; zinc ion binding;

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