Recombinant Human ING1 Protein, GST-tagged
Cat.No. : | ING1-5132H |
Product Overview : | Human ING1 full-length ORF ( NP_937862.1, 1 a.a. - 279 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 58.3 kDa |
AA Sequence : | MLSPANGEQLHLVNYVEDYLDSIES LPFDLQRNVSLMREIDAKYQEILKE LDECYERFSRETDGAQKRRMLHCVQ RALIRSQELGDEKIQIVSQMVELVE NRTRQVDSHVELFEAQQELGDTAGN SGKAGADRPKGEAAAQADKPNSKRS RRQRNNENRENASSNHDHDDGASGT PKEKKAKTSKKKKRSKAKAEREASP ADLPIDPNEPTYCLCNQVSYGEMIG CDNDECPIEWFHFSCVGLNHKPKGK WYCPKCRGENEKTMDKALEKSKKER AYNR |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ING1 inhibitor of growth family, member 1 [ Homo sapiens ] |
Official Symbol : | ING1 |
Synonyms : | ING1; inhibitor of growth family, member 1; inhibitor of growth protein 1; growth inhibitor ING1; growth inhibitory protein ING1; inhibitor of growth 1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a; tumor suppressor ING1; |
Gene ID : | 3621 |
mRNA Refseq : | NM_005537 |
Protein Refseq : | NP_005528 |
MIM : | 601566 |
UniProt ID : | Q9UK53 |
Products Types
◆ Recombinant Protein | ||
ING1-2405H | Recombinant Human ING1 Protein, MYC/DDK-tagged | +Inquiry |
Ing1-3535M | Recombinant Mouse Ing1 Protein, Myc/DDK-tagged | +Inquiry |
ING1-4542M | Recombinant Mouse ING1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ING1-2089R | Recombinant Rhesus Macaque ING1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ING1-28775TH | Recombinant Human ING1 | +Inquiry |
◆ Lysates | ||
ING1-860HCL | Recombinant Human ING1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionING1 was identified through a protein microarray screening method using protein microarrays (ProtoArray).
Elevated levels of anti-ING1 antibodies were observed not only in CRC but also in esophageal cancer (EC), gastric cancer (GC), breast cancer (BrC), and pancreatic cancer (PC).
Antibodies against ING1 amino acids between 239 and 253 were found at significantly higher levels in patients with CRC compared to other cancer types.
Immunohistochemical staining revealed higher expression of ING1 protein in CRC cells than in adjacent normal tissues.
Anti-ING1 antibody levels were significantly higher in CRC patients at all stages compared to HDs.
ING1 has been identified as a candidate tumor antigen for CRC and shows potential as a biomarker for this cancer type.
ING1 was found to augment p53-mediated NOXA promoter activity but attenuate p53-stimulated Bax, p21, and PUMA promoter activities in CRC cell line experiments.
Customer Reviews (3)
Write a reviewThe product’s innovative characteristics enabled us to explore previously uncharted territories within cellular mechanisms.
The value derived from the product’s usage made the investment worthwhile, considering the knowledge acquired.
Replicating results underscored the reliability and relevance of the product’s effects.
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