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Recombinant Human ING1 Protein, GST-tagged

Cat.No. : ING1-5132H
Product Overview : Human ING1 full-length ORF ( NP_937862.1, 1 a.a. - 279 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 58.3 kDa
AA Sequence : MLSPANGEQLHLVNYVEDYLDSIES LPFDLQRNVSLMREIDAKYQEILKE LDECYERFSRETDGAQKRRMLHCVQ RALIRSQELGDEKIQIVSQMVELVE NRTRQVDSHVELFEAQQELGDTAGN SGKAGADRPKGEAAAQADKPNSKRS RRQRNNENRENASSNHDHDDGASGT PKEKKAKTSKKKKRSKAKAEREASP ADLPIDPNEPTYCLCNQVSYGEMIG CDNDECPIEWFHFSCVGLNHKPKGK WYCPKCRGENEKTMDKALEKSKKER AYNR
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ING1 inhibitor of growth family, member 1 [ Homo sapiens ]
Official Symbol : ING1
Synonyms : ING1; inhibitor of growth family, member 1; inhibitor of growth protein 1; growth inhibitor ING1; growth inhibitory protein ING1; inhibitor of growth 1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a; tumor suppressor ING1;
Gene ID : 3621
mRNA Refseq : NM_005537
Protein Refseq : NP_005528
MIM : 601566
UniProt ID : Q9UK53

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How was ING1 identified as a candidate tumor antigen for CRC? 09/21/2022

ING1 was identified through a protein microarray screening method using protein microarrays (ProtoArray).

In which other types of cancer were increased levels of anti-ING1 antibodies detected? 09/21/2019

Elevated levels of anti-ING1 antibodies were observed not only in CRC but also in esophageal cancer (EC), gastric cancer (GC), breast cancer (BrC), and pancreatic cancer (PC).

Are there specific regions of the ING1 protein associated with CRC? 02/06/2019

Antibodies against ING1 amino acids between 239 and 253 were found at significantly higher levels in patients with CRC compared to other cancer types.

What was the result of immunohistochemical staining for ING1 protein in CRC cells? 01/21/2019

Immunohistochemical staining revealed higher expression of ING1 protein in CRC cells than in adjacent normal tissues.

How do serum anti-ING1 antibody levels in CRC patients compare to healthy donors (HDs)? 03/14/2018

Anti-ING1 antibody levels were significantly higher in CRC patients at all stages compared to HDs.

What is the significance of ING1 in the context of colorectal cancer (CRC)? 02/10/2018

ING1 has been identified as a candidate tumor antigen for CRC and shows potential as a biomarker for this cancer type.

What effect does ING1 have on specific promoters in CRC cells? 03/24/2017

ING1 was found to augment p53-mediated NOXA promoter activity but attenuate p53-stimulated Bax, p21, and PUMA promoter activities in CRC cell line experiments.

Customer Reviews (3)

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Reviews
11/07/2020

     The product’s innovative characteristics enabled us to explore previously uncharted territories within cellular mechanisms.

    09/03/2019

       The value derived from the product’s usage made the investment worthwhile, considering the knowledge acquired.

      03/05/2018

         Replicating results underscored the reliability and relevance of the product’s effects.

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