"PBRM1" Related Products


Recombinant Human PBRM1, His&FLAG-tagged

Cat.No.: PBRM1-59H
Product Overview: Recombinant Human PBRM1 corresponding to amino acids 613 - 734 that contains the bromodomain sequences of PBRM1 (accession number NP_060635.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 20.513 kDa.
Description: Polybromo 1 (PBRM1) protein, also known as BRG1-associated factor 180 (BAF180) is the chromatin targeting subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex that is involved in transcriptional activation and repression of select genes. PBRM1 targets chromatin via its six bromodomains that recognize and bind acetylated histone lysine residues. Bromodomains function as "readers" of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. PBRM1 also acts as an inhibitor of cell proliferation and demonstrates tumor suppressing properties in relation to breast, liver and lung cancers.
Source: E. coli
Species: Human
Tag: His&FLAG
Form: 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol.
Bio-activity: It shows binding specificity for acetylated H3K14.
Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Concentration: 2.98 mg/ml
Gene Name: PBRM1 polybromo 1 [ Homo sapiens ]
Official Symbol: PBRM1
Synonyms: PBRM1; polybromo 1; protein polybromo-1; BAF180; PB1; polybromo-1D; BRG1-associated factor 180; MGC156155; MGC156156;
Gene ID: 55193
mRNA Refseq: NM_018313
Protein Refseq: NP_060783
MIM: 606083
UniProt ID: Q86U86
Chromosome Location: 3p21
Function: DNA binding; chromatin binding; protein binding;

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