||Recombinant Humanα-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques (140 aa, 14.4 kDa).
||α-Synuclein E46K is a mutant form of α-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant (E46K) of α-synuclein causes Parkinson and Lewy Body dementia(DLB).
||Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
||14.4 kDa (Real molecular size on SDS-PAGE will be shift up).
||> 95% by SDS – PAGE.
||1 mg/ml (determined by BCA assay).
||MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
||Store at -20 °C. Avoid freeze/thaw cycles.