Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), E46K

Cat. No. : SNCA-294H
Product Overview : Recombinant Humanα-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques (140 aa, 14.4 kDa).
Description : α-Synuclein E46K is a mutant form of α-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant (E46K) of α-synuclein causes Parkinson and Lewy Body dementia(DLB).
Source : E.coli.
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
Molecular Weight : 14.4 kDa (Real molecular size on SDS-PAGE will be shift up).
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by BCA assay).
Sequence : MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Storage : Store at -20 °C. Avoid freeze/thaw cycles.
Gene Name : SNCA
Synonyms : SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP).
Gene ID : 6622
mRNA Refseq : NM_000345.3
Protein Refseq : NP_000336.1
MIM : 163890
UniProt ID : P37840
Chromosome Location : 4q21
Pathway : Alzheimer"s disease;Neurodegenerative Disorders; Parkinson"s disease.
Function : Hsp70 protein binding;alpha-tubulin binding; dynein binding; histone binding; kinesin binding; tau protein binding; transferrin transmembrane transporter activity.

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.