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Recombinant Human PTH

Cat.No.: PTH-04H
Product Overview: Recombinant Human PTH(1aa-84aa) was expressed in E. coli.
Description: Parathyroid hormone (PTH) is a single polypeptide of 84 amino acids. It is a critical hormone in the regulation of Ca2+ homeostasis and secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low.
Source: E. coli
Species: Human
Form: Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 10^4 IU/mg.
Molecular Mass: Approximately 9.4 kDa, a single non-glycosylated polypeptide chain containing 84 amino acids.
AA Sequence: SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
Endotoxin: Less than 1 EU/µg of rHuPTH1-84 as determined by LAL method.
Purity: > 97 % by SDS-PAGE and HPLC analyses.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: PTH parathyroid hormone [ Homo sapiens ]
Official Symbol: PTH
Synonyms: PTH1; parathyroid hormone; parathormone; parathyrin; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone
Gene ID: 5741
mRNA Refseq: NM_000315
Protein Refseq: NP_000306
MIM: 168450
UniProt ID: P01270
Chromosome Location: 11p15.3-p15.1
Pathway: Class B/2 (Secretin family receptors), organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem
Function: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; hormone activity; parathyroid hormone receptor binding

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