Recombinant Human KIR2DL1

• Cat.No.: KIR2DL1-145H
• Product Overview: Recombinant killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 produced inE.Coliis a single,non-glycosylated polypeptide chain. The protein contains 202 amino acids and has a molecular mass of 22.2 kDa.

Specification

• Cat. No.: KIR2DL1-145H
• Description: An inhibitory Keller Cell Ig-like Receptor(KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules(HLA-Cw2, -Cw4, -Cw5, and Cw6). The extracellular domain of KIR2DL1 was over expressed as insoluble protein aggregates(inclusion bodies).
• Source: Escherichia Coli.
• Amino Acid Sequence: MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN.
• Physical Appearance: Sterile filtered clorless solution.
• Formulation: The protein (1mg/ml) contains 25mM Tris-HCl (pH7.5).
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by reducing and non-reducing SDS-PAGE Coomassie.
• Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Gene Information

• Gene Name: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 [ Homo sapiens ]
• Synonyms: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; NKAT; NKAT1; p58.1; CD158A; KIR221; KIR-K64; KIR2DL1; killer inhibitory receptor 2-2-1; p58 natural killer cell receptor; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58 killer cell inhibitory receptor KIR-K64; cl-42; nkat1; 47.11; NKAT-1; CD158 antigen-like family member A; CD158a antigen; MHC class I NK cell receptor; Natural killer-associated transcript 1; p58 NK receptor; p58 natural killer cell receptor clones CL-42/47.11; p58.1 MHC class-I-specific NK receptor
• Gene ID: 3802
• mRNA Refseq: NM_014218
• Protein Refseq: NP_055033
• MIM: 604936
• UniProt ID: P43626
• Pathway: Antigen processing and presentation; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Signaling in Immune system
• Function: receptor activity