| Cat. No.: | OTUB1-482H |
| Product Overview: | Recombinant OTUB1 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 33.4 kDa (291aa). |
| Description: | Otubain 1, also known as OTUB1, is a member of the OUT (ovarian tumor) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system via its interaction with a ubiquitin protease and E3 ubiquitin ligase. This protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. |
| Source: | E.coli. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K |
| Form: | Liquid. In 20 mM Tris buffer (pH 8.0) containing 10% glycerol. |
| Purity: | > 95% by SDS – PAGE. |
| Concentration: | 1 mg/ml (determined by Bradford assay). |
| Storage: | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| Gene Name: | OTUB1 OTU domain, ubiquitin aldehyde binding 1 [ Homo sapiens ] |
| Synonyms: | OTUB1; OTU domain, ubiquitin aldehyde binding 1; OTB1; OTU1; HSPC263; MGC4584; FLJ20113; FLJ40710; MGC111158;OTU-domain Ubal-binding 1; ubiquitin-specific protease otubain 1; Ubiquitin thioesterase OTUB1; Otubain-1; OTU domain-containing ubiquitin; aldehyde-binding protein 1; Ubiquitin-specific-processing protease; Deubiquitinating enzyme OTUB1 |
| Gene ID: | 55611 |
| mRNA Refseq: | NM_017670 |
| Protein Refseq: | NP_060140 |
| MIM: | 608337 |
| UniProt ID: | Q96FW1 |
| Chromosome Location: | 11q13.1 |
| Function: | cysteine-type peptidase activity; peptidase activity |
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