Recombinant Human OTUB1 Protein (A25-K271), Flag tagged
Cat.No. : | OTUB1-0548H |
Product Overview : | Recombinant Human OTUB1(A25-K271 end)-Flag Protein was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. |
Source : | E. coli |
Species : | Human |
Tag : | Flag |
Form : | Liquid |
Protein Length : | A25-K271 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | OTUB1 OTU domain, ubiquitin aldehyde binding 1 [ Homo sapiens (human) ] |
Official Symbol : | OTUB1 |
Synonyms : | OTUB1; OTU domain, ubiquitin aldehyde binding 1; ubiquitin thioesterase OTUB1; FLJ20113; FLJ40710; otubain-1; OTU-domain Ubal-binding 1; deubiquitinating enzyme OTUB1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTB1; OTU1; HSPC263; MGC4584; MGC111158; |
Gene ID : | 55611 |
mRNA Refseq : | NM_017670 |
Protein Refseq : | NP_060140 |
MIM : | 608337 |
UniProt ID : | Q96FW1 |
Products Types
◆ Recombinant Protein | ||
OTUB1-6433M | Recombinant Mouse OTUB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
OTUB1-3880R | Recombinant Rat OTUB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Otub1-323M | Recombinant Mouse Otub1 Protein, MYC/DDK-tagged | +Inquiry |
OTUB1-01H | Active Recombinant Human OTUB1 Protein, His-tagged | +Inquiry |
OTUB1-0549H | Recombinant Human OTUB1 Protein (A25-K271), GST/Flag tagged | +Inquiry |
◆ Lysates | ||
OTUB1-3516HCL | Recombinant Human OTUB1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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