Recombinant Human GBA
| Cat.No. : | GBA-28984TH |
| Product Overview : | Recombinant full length Human GBA with a N terminal proprietary tag: predicted molecular weight 84.70 kDa. |
- Specification
- Gene Information
- Related Products
| Description : | This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. |
| Protein length : | 536 amino acids |
| Molecular Weight : | 84.700kDa inclusive of tags |
| Source : | Wheat germ |
| Form : | Liquid |
| Purity : | Proprietary Purification |
| Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : | MEFSSPSREECPKPLSRVSIIAGSLTGLLLLQAVSWASGA RPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYE STRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRV PMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLI HRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLL SGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLML DDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGM QYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSP IIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLE TISPGYSIHTYLWRRQ |
| Sequence Similarities : | Belongs to the glycosyl hydrolase 30 family. |
| Gene Name : | GBA glucosidase, beta, acid [ Homo sapiens ] |
| Official Symbol : | GBA |
| Synonyms : | GBA; glucosidase, beta, acid; GLUC, glucosidase, beta; acid (includes glucosylceramidase) , glucosylceramidase; glucosylceramidase; GBA1; |
| Gene ID : | 2629 |
| mRNA Refseq : | NM_000157 |
| Protein Refseq : | NP_000148 |
| MIM : | 606463 |
| Uniprot ID : | P04062 |
| Chromosome Location : | 1q22 |
| Pathway : | Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem; Other glycan degradation, organism-specific biosystem; Other glycan degradation, conserved biosystem; |
| Function : | cation binding; glucosylceramidase activity; hydrolase activity, acting on glycosyl bonds; receptor binding; |
Products Types
| ◆ Recombinant Protein | ||
| GBA-4764H | Recombinant Human GBA Protein, GST-tagged | +Inquiry |
| GBA-539H | Recombinant Human GBA Protein (Ala40-Gln536), His-tagged | +Inquiry |
| Gba-3165M | Recombinant Mouse Gba Protein, Myc/DDK-tagged | +Inquiry |
| GBA-3492M | Recombinant Mouse GBA Protein, His (Fc)-Avi-tagged | +Inquiry |
| GBA-2218H | Recombinant Human GBA protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| GBA-6002HCL | Recombinant Human GBA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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