Recombinant Human Fas (TNF Receptor Superfamily, Member 6)
Cat.No. : | FAS-1615H |
- Specification
- Gene Information
- Related Products
Cat. No. : | FAS-1615H |
Description : | Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Human sFasR is 45 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human Soluble Fas Receptor is determined by its ability to inhibit the cytotoxicity of Jurkat cells. The expected ED50 for this effect is 10-15 mg/ml in the presence of 2 ng/ml of human FasL. |
Storage : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] |
Synonyms : | FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen |
Gene ID : | 355 |
mRNA Refseq : | NM_000043 |
Protein Refseq : | NP_000034 |
MIM : | 134637 |
UniProt ID : | P25445 |
Chromosome Location : | 10q24.1 |
Pathway : | Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis |
Function : | identical protein binding; kinase binding; transmembrane receptor activity |
Products Types
◆ Recombinant Protein | ||
FAS-4403H | Recombinant Human FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-70H | Recombinant Active Human FAS Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
FAS-3850H | Recombinant Human FAS Protein | +Inquiry |
Fas-12R | Recombinant Rat Fas Protein, His (Fc)-Avi-tagged | +Inquiry |
Fas-3268M | Active Recombinant Mouse Fas protein(Met1-Arg169), His-tagged | +Inquiry |
◆ Lysates | ||
FAS-2185HCL | Recombinant Human FAS cell lysate | +Inquiry |
FAS-2419MCL | Recombinant Mouse FAS cell lysate | +Inquiry |
FAS-001CCL | Recombinant Cynomolgus FAS cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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