"FAS" Related Products

Recombinant Human Fas (TNF Receptor Superfamily, Member 6)

Cat. No.: FAS-1615H
Description: Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
Source: NSO cells.
Molecular Weight: The predicted molecular weight of Recombinant Human sFasR is 45 kDa.
State Of Matter: Lyophilized.
Purity: >97% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
Biological Activity: The biological activity of Human Soluble Fas Receptor is determined by its ability to inhibit the cytotoxicity of Jurkat cells. The expected ED50 for this effect is 10-15 mg/ml in the presence of 2 ng/ml of human FasL.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ]
Synonyms: FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen
Gene ID: 355
mRNA Refseq: NM_000043
Protein Refseq: NP_000034
MIM: 134637
UniProt ID: P25445
Chromosome Location: 10q24.1
Pathway: Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis
Function: identical protein binding; kinase binding; transmembrane receptor activity

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