FAS

  • Official Full Name

    Fas cell surface death receptor

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
  • Synonyms

    FAS; Fas cell surface death receptor; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
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  • Cynomolgus Monkey
  • Feline
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Rat
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
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  • Human Cell
  • Human cells
  • Human Cells
  • Human Embryo Kidney
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • Fc Chimera
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • His|GST
  • His|MBP
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FAS-519H Active Recombinant Human FAS E.coli N/A
Human FAS-603H Active Recombinant Human FAS, Fc-tagged, Biotinylated Human Cell Fc
Human FAS-281H Recombinant Human FAS, His & GST tagged Human Cell His/GST
Human FAS-1411H Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6) Human Embryo Kidney N/A
Human FAS-614H Recombinant Human FAS protein, His-tagged E.coli His Gln26~Asn173 (Accession # P25445)
Human FAS-26332TH Recombinant Human FAS protein E.coli N/A 157
Human FAS-3154H Active Recombinant Human Fas protein, His-tagged HEK293 His Met1-Asn173
Human FAS-5411H Recombinant Human Fas (TNF receptor superfamily, member 6) E.coli N/A
Human FAS-616H Recombinant Human FAS protein, His & MBP-tagged E.coli His/MBP Ser22~Ser172 (Accession # P25445)
Human FAS-3814H Recombinant Human Fas (TNF receptor superfamily, member 6) Human N/A
Human FAS-27896TH Recombinant Human FAS, His-tagged E.coli His 164 amino acids
Human FAS-4270H Recombinant Human Fas (TNF Receptor Superfamily, Member 6) Human N/A
Human FAS-3850H Recombinant Human FAS Protein Wheat Germ N/A
Human FAS-1615H Recombinant Human Fas (TNF Receptor Superfamily, Member 6) Mammalian cells N/A
Human FAS-3853H Recombinant Human FAS Protein, GST-tagged Wheat Germ GST
Human FAS-37H Recombinant Human Fas Ligand Inhibitor, Fc-tagged Fc
Human FAS-5265H Recombinant Human Fas (TNF receptor superfamily, member 6) Human Embryo Kidney N/A
Human FAS-239H Active Recombinant Human FAS, Fc-tagged HEK293 Fc
Human FAS-602H Recombinant Human FAS protein, Fc-tagged HEK293 human/IgG1/Fc Gln26-Asn173
Human FAS-38H Recombinant Human Fas Ligand soluble, FLAG-tagged HEK293 Flag
Human FAS-12751H Recombinant Human FAS, GST-tagged E.coli GST C-term-180a.a.
Human FAS-16H Recombinant Human FAS protein, MYC/DDK-tagged HEK293 Myc/DDK
Human Fas-026H Active Recombinant Human Fas protein, Fc-tagged HEK293 Fc Gln26-Asn173
Human FAS-3851H Recombinant Human FAS Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
Human Fas-027H Recombinant Human Fas protein, His-tagged HEK293 His Gln26-Asn173
Human FAS-615H Recombinant Human FAS protein, His & GST-tagged E.coli His/GST Ser22~Ser172 (Accession # P25445)
Human FAS-2185HCL Recombinant Human FAS cell lysate Human Cell N/A
Human CDA093P Recombinant Human CD95 E.coli N/A
Human FAS-70H Recombinant Active Human FAS Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gln26-Asn173
Human FAS-4772HF Recombinant Full Length Human FAS Protein In Vitro Cell Free System 198 amino acids
Human FAS-4983H Recombinant Human FAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FAS-151H Recombinant Human FAS Protein, His-tagged Human Cells His
Human FAS-2374H Recombinant Human FAS Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 26-335aa
Human FAS-2288H Recombinant Human FAS Protein (Gln26-Asn173), C-His tagged Mammalian cells C-His Gln26-Asn173
Human FAS-2893HFL Recombinant Full Length Human FAS protein, Flag-tagged Mamanlian cells Flag
Human FAS-4403H Recombinant Human FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDA074P Recombinant Human CD-95, His Tag E.coli N/A
Human FAS-242H Recombinant Human FAS Protein, His-tagged HEK293 His 335
Human FAS-4858HF Recombinant Full Length Human FAS Protein, GST-tagged In Vitro Cell Free System GST 335 amino acids
Human FAS-243H Recombinant Human FAS Protein, Fc-tagged HEK293 Fc 335
Human FAS-2664H Active Recombinant Human FAS protein, hFc&His-tagged HEK293 hFc&His Gln26-Asn173
Human FAS-4403H-B Recombinant Human FAS Protein Pre-coupled Magnetic Beads HEK293
Human FAS-2287H Recombinant Human FAS Protein (Gln26-Asn173), C-Fc tagged Mammalian cells C-Fc Gln26-Asn173
Human FAS-0713H Recombinant Human FAS Protein (Met1-Asn173), C-His tagged Mammalian cells C-His Met1-Asn173
Mouse Fas-618M Recombinant Mouse Fas protein, His-tagged E.coli His Lys188~Asn319 (Accession # P25446)
Mouse Fas-1735M Recombinant Mouse Fas (TNF Receptor Superfamily Member 6) Sf21 Insect Cell N/A
Mouse Fas-617M Recombinant Mouse Fas protein, His-tagged E.coli His Gln22~Arg169
Mouse Fas-3268M Active Recombinant Mouse Fas protein(Met1-Arg169), His-tagged HEK293 C-His Met1-Arg169
Mouse FAS-2419MCL Recombinant Mouse FAS cell lysate Human Cell N/A
Mouse Fas-5660M Recombinant Mouse Fas Protein (Gln22-Arg169), C-Fc tagged Mammalian cells C-Fc Gln22-Arg169
Mouse Fas-5661M Recombinant Mouse Fas Protein (Gln22-Arg169), C-His tagged Mammalian cells C-His Gln22-Arg169
Mouse Fas-1020M Recombinant Mouse Fas Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Fas-823R Active Recombinant Rat Fas Protein, Fc Chimera Mammalian cells Fc
Rat FAS-2273R Recombinant Rat FAS Protein Mammalian Cell His
Rat Fas-4096R Active Recombinant Rat Fas protein, His-tagged HEK293 His Met1-Lys170
Rat Fas-620R Recombinant Rat Fas protein, His & GST-tagged E.coli His/GST Met21~Lys170 (Accession # Q63199)
Rat FAS-547R Recombinant Rat FAS protein(Met1-Lys170), hFc-tagged HEK293 C-hFc Met1-Lys170
Rat Fas-622R Recombinant Rat Fas protein, His & MBP-tagged E.coli His/MBP Met21~Lys170 (Accession # Q63199)
Rat Fas-486R Recombinant Rat Fas protein, His-tagged HEK293F His Gln22~Leu171
Rat FAS-1139RCL Recombinant Rat FAS cell lysate Human Cell N/A
Rat Fas-12R-B Recombinant Rat Fas Protein Pre-coupled Magnetic Beads HEK293
Rat Fas-12R Recombinant Rat Fas Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL539BF Recombinant Full Length Bovine Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-323)
Cattle FAS-613C Recombinant Cattle FAS protein, His & T7-tagged E.coli His/T7 Leu37~Tyr274
Cattle FAS-921C Recombinant Cattle FAS Protein, His&GST-tagged E.coli N-His&GST Leu37-Tyr274
Cynomolgus FAS-2183C Active Recombinant Cynomolgus FAS protein, hFc-tagged HEK293 hFc Met1-Asp173
Cynomolgus Monkey FAS-142C Recombinant Cynomolgus FAS, Fc tagged Human Cell His/GST
Cynomolgus Monkey FAS-203C Recombinant Cynomolgus FAS Human Cell N/A Met1-Asp173
Cynomolgus Monkey FAS-513C Recombinant Cynomolgus FAS Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey FAS-001CCL Recombinant Cynomolgus FAS cell lysate Human Cell N/A
Cynomolgus Monkey FAS-258C Recombinant Cynomolgus Monkey FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey FAS-258C-B Recombinant Cynomolgus Monkey FAS Protein Pre-coupled Magnetic Beads HEK293
Feline FAS-635F Active Recombinant Feline FAS, Fc Chimera Mammalian cells Fc Chimera
Feline FAS-2F Recombinant Feline FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Feline FAS-2F-B Recombinant Feline FAS Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL6573HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-335aa)
Mus musculus (Mouse) RFL9899MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-327)
Rhesus Macaque FAS-1644R Recombinant Rhesus monkey FAS Protein, His-tagged Mammalian Cell His
Rhesus Macaque FAS-1468R-B Recombinant Rhesus Macaque FAS Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FAS-1468R Recombinant Rhesus Macaque FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL17912SF Recombinant Full Length Pig Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-332)
Pig FAS-619P Recombinant Pig FAS protein, His & GST-tagged E.coli His/GST Glu48~Tyr281
Chicken FAS-4338C Recombinant Chicken FAS Mammalian Cell His
  • Background
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  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FAS Related Signal Pathway
FAS-9.jpg

Fig1. Intron-exon structure of FAS gene delineating the exons coding for the extracellular, transmembrane, and intracellular portions of FAS. (Filippo Consonni, 2022)

What is FAS protein?

FAS (Fas cell surface death receptor) gene is a protein coding gene which situated on the long arm of chromosome 10 at locus 10q23. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. The FAS protein is consisted of 335 amino acids and its molecular mass is approximately 37.7 kDa.

What is the function of FAS protein?

FAS is a membrane protein that belongs to the tumor necrosis factor receptor family. Its function is mainly reflected in the regulation of apoptosis and immune response. When Fas binds to its ligand FasL, it activates the protease of the caspase family, triggering an intracellular apoptotic signaling pathway, leading to programmed cell death. This process is important for maintaining immune system homeostasis, removing damaged or abnormal cells, and preventing the development of tumors. In addition, Fas is involved in other biological processes, such as cell proliferation, differentiation, and migration.

FAS Related Signaling Pathway

Fas (also called CD95/APO-1) is a cell surface death receptor that is mainly involved in signaling pathways associated with apoptosis. When Fas binds to its ligand FasL, it induces the formation of a death-inducing signaling complex (DISC), which in turn activates initiating caspases in the caspase family, such as Caspase-8 and Caspase-10. These activated caspases further activate downstream effector caspases, such as caspase-3, triggering the hydrolysis of a series of proteins, ultimately leading to the appearance of the typical morphological and biochemical features of apoptosis. In addition to its core role in the extrinsic pathway of apoptosis, Fas signaling may also interact with other signaling pathways, such as the NF-κB pathway and the MAPK pathway, to play roles in inflammatory responses, cell proliferation, and immune regulation.

FAS-10.jpg

Fig2. Soluble CD95L triggers the Motility-induced Signaling Complex (MISC) formation. (Jean-Philippe Guégan, 2018)

FAS Related Diseases

Mutations or abnormal expression of Fas gene may lead to impairment of Fas mediated apoptosis mechanism, allowing immune cells that should die to survive, thus triggering autoimmune diseases. Certain types of cancer, such as lymphoma and leukemia, have been found to be associated with defects in the Fas signaling pathway. It may also be associated with myelosuppression, which affects blood cell production. Liver diseases such as hepatitis and cirrhosis, and neurological diseases such as multiple sclerosis may also be associated with abnormal activity of Fas signaling pathways.

Bioapplications of FAS

On the clinical side, excitatory antibodies and antagonistic antibodies of Fas are being explored for tumor therapy and the treatment of autoimmune diseases. For example, inducing tumor cell apoptosis by activating the Fas pathway is a potential cancer treatment strategy. At the same time, inhibitors of the Fas pathway may play a role in preventing organ transplant rejection or treating certain autoimmune diseases.

Case study 1: Laurent Gagnoux-Palacios, 2018

Finely tuned regulation of epithelial cell death maintains tissue integrity and homeostasis. At the cellular level, life and death decisions are controlled by environmental stimuli such as the activation of death receptors. We show that cell polarity and adherens junction formation prevent proapoptotic signals emanating from the Fas death receptor. Fas is sequestered in E-cadherin actin-based adhesion structures that are less able to induce downstream apoptosis signaling. Using a proteomic-based approach, we find that the polarity molecule Dlg1 interacts with the C-terminal PDZ-binding site in Fas and that this interaction decreases formation of the death-inducing complex upon engagement with Fas ligand (FasL), thus acting as an additional cell death protection mechanism. Thus E-cadherin and Dlg1 inhibit FasL-induced cell death by two complementary but partially independent mechanisms that help to maintain epithelial homeostasis by protecting normal polarized epithelia from apoptosis. When polarity is lost, the Fas-cadherin-Dlg1 antiapoptotic complex is disrupted, and FasL can promote the elimination of compromised nonpolarized cells.

FAS-3.jpg

Fig1. Fas detergent solubility in HCT15 cells transfected by the indicated siRNAs was analyzed by IB.

FAS-4.jpg
Fig2. Accumulation of Fas and activated caspase-8 under FasL-coated beads was quantified.

Case study 2: María Florencia Sánchez, 2018

The cytotoxic synapse formed between cytotoxic T lymphocytes or natural killer cells expressing CD95L and target cells with CD95 on their surface is a key pathway for apoptosis induction by the immune system. Despite similarities with the immune synapse in antigen presenting cells, little is known about the role of the spatiotemporal organization of agonistic proteins/receptor interactions for CD95 signaling. Here, the researchers have developed an artificial cytotoxic synapse to examine how mobility and geometry of an anti-CD95 agonistic antibody affect receptor aggregation and mobility.

By measuring the distribution, diffusion coefficient, and fraction of immobile CD95 receptor in living cells, we show that at short times, the initial activation of CD95 occurs locally and is limited to the contact region of the cytotoxic synapse. This anisotropic activation of apoptotic signaling supports a role for confined interactions on the efficiency of signal transduction that may have implications for biomedical applications of extrinsic apoptosis induction.

FAS-5.jpg

Fig3. Effector Caspases 3/7 activity measured by luminescence in CD95 ko T98G cells.

FAS-6.jpg
Fig4. Diffusion coefficients of CD95 as obtained by FCS.
FAS-7.jpg

Fig1. Extrinsic and intrinsic apoptotic pathways. (Jean-Philippe Guégan, 2018)

FAS-8.jpg

Fig2. Fas-FasL interactions mediate immune cell homeostasis. (R M Siegel, 2000)

FAS involved in several pathways and played different roles in them. We selected most pathways FAS participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNG2A;ARRB2;FGF2;PPP3CB;CACNA1SB;MKNK2B;CACNG7A;FGF21;MAP2K6
Cytokine-cytokine receptor interactionPDGFRA;TGFBR1;CXCR3.2;TNFSF13;TSLP;CCL19B;FAS;ACVR1B;MET
p signaling pathwayRPRM;BBC3;PMAIP1;RCHY1;TP53;BAXA;PPM1DB;RFWD2;PIDD1
ApoptosisDCC;CYCS;MYC;DNM1L;DAPK3;Casp3;Gzmg;AIFM1;BIRC8
Natural killer cell mediated cytotoxicityPAK1;FASLG;IFNA21;IFNAR1;MICA;KIR3DL1;MAPK3;TNFRSF10D;KIR2DL3
TNF signaling pathwayTNFRSF1A;TRAF1;CASP10;CXCL3;PIK3CD;IL18R1;IL15;TRAF5;TNFRSF1B
Non-alcoholic fatty liver disease (NAFLD)NDUFV1;SDHD;ADIPOQ;NDUFA2;ADIPOR1;PIK3CG;MAPK8;PRKAB1;NDUFS7
Type I diabetes mellitusGAD1;FASLG;IL12A;HLA-DPB1;H2-AB1;HLA-DQA1;IFNG;LTA;CPE
Alzheimers diseaseCOX7A2L;COX7A2;LRP1;NOS1;CASP12;ITPR3;NAE1;UQCRH;ATP5A1
Chagas disease (American trypanosomiasis)PLCB1;CCL3;PPP2R2B;GNAI2;C3;TLR6;MAPK8;GNA15;PLCB3
African trypanosomiasisIL6;PLCB4;IL1B;FASLG;APOL1;IDO1;HBA2;HBB-B1;IFNG
Hepatitis BHBXIP;TGFB1;IFNA17;VDAC3;PTEN;TLR3;CREB3L2;GRB2;BAD
MeaslesTACR1;TP73;CCNE1;AKT2;PIK3CD;Fasl;NFKBIA;OAS3;TNFRSF10B
Influenza ARAF1;IL33;HSPA1A;PIK3CG;EP300;AKT1;VDAC1;PIK3CB;IL8L2
Herpes simplex infectionALYREF;FADD;BF2;CUL1A;EP300;LOC100033925;POLR2A;HMGN1;HLA-DOB
Pathways in cancerSMAD4;PIK3CD;GLI2;AKT1;PTCH1;CXCR4;GSTP1;FGF9;PTGER3
Proteoglycans in cancerSMAD2;MAPK3;GPC1;FZD6;FN1;RAC1;ERBB2;DDX5;TWIST2
AutoiIFNA7;GZMB;HLA-DPA1;HLA-B;HLA-A;IL5;IFNA1;Fasl;TSHB
ne thyroid diseaseHLA-DRB1;IFNA16;HLA-DQB1;HLA-DQA2;HLA-F;IFNA17;HLA-E;CD40;IFNA10
Allograft rejectionCD40LG;Il2;HLA-DRB1;HLA-A;HLA-DQA1;MICA;GZMB;IL4;HLA-DRB5
Graft-versus-host diseaseKIR2DL1;CD28;KIR3DL1;HLA-DPB1;HLA-A;HLA-B;PRF1;CD86;KLRD1

FAS has several biochemical functions, for example, identical protein binding, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAS itself. We selected most functions FAS had, and list some proteins which have the same functions with FAS. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingCLDN17;TPRGL;WAS;DRG1;ASMT;PAICS;Serpina1c;COL2A1;EPHA4
kinase bindingCHP;CDC37;CAB39;PARK2;DGKQ;PRKCD;HPCA;PARP16;RPS3
protein bindingP2RY6;LNX2B;RPS16;DDX3X;CAPN2;TREML1;TREX1;USP33;RB1
receptor activityCLEC4E;MED16;ADIPOR1A;GRIA3A;NPR2;MED30;GFRA1A;AGER;CADM1
signal transducer activityCXCR7B;PLCB1;NDFIP1;TAS2R103;GNG12;PLCD1A;PLCH1;OPN1SW2;OLFR867
tumor necrosis factor-activated receptor activityTNFRSF11A;TNFRSF9A;RELT;TNFRSF10D;TNFRSF18;TNFRSF19;TNFRSF1A;TNFRSF10C;TNFRSF25

FAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAS here. Most of them are supplied by our site. Hope this information will be useful for your research of FAS.

FADD

Research Area

Related articles

Choi, BD; Jeong, SJ; et al. The Effect of Thymosin beta 4 for Osteoblast Adhesion on Titanium Surface. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5663-5667(2015).
Rutkowska, J; Bialek, M; et al. Differentiation of geographical origin of cream products in Poland according to their fatty acid profile. FOOD CHEMISTRY 178:26-31(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Does FAS protein play a role in cell signaling? 10/30/2022

FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

Why apply knowledge of FAS proteins to clinical practice? 06/27/2022

It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

How can diseases associated with FAS protein be prevented and treated? 05/13/2022

FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

How can gene knockout or knockdown techniques be used to study the function of FAS proteins? 03/31/2021

Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

What is the role of FAS protein in apoptosis? 09/29/2020

FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

How can FAS protein be used to predict disease prognosis? 06/19/2020

The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.

Customer Reviews (3)

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Reviews
09/07/2022

    When experimenting with FAS, the results are very reproducible.

    07/29/2022

      The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

      09/20/2021

        FAS has high specific activity and can exert strong biological effect at low concentration.

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