Recombinant Human HPD

• Cat.No.: HPD-28754TH
• Product Overview: Recombinant Full Length Human HPD produced in Saccharomyces cerevisiae; amino acids 1-393; 393 amino acids, 44.9kDa.

Specification

• Description: The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKM GFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNK EMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMRE PWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGY EAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWY LKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRH LRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEEL KILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFG AGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM

Gene Information

• Gene Name: HPD 4-hydroxyphenylpyruvate dioxygenase [ Homo sapiens ]
• Official Symbol: HPD
• Synonyms: HPD; 4-hydroxyphenylpyruvate dioxygenase; PPD; 4 HPPD; 4HPPD; GLOD3; glyoxalase domain containing 3
• Gene ID: 3242
• mRNA Refseq: NM_001171993
• Protein Refseq: NP_001165464
• MIM: 609695
• Uniprot ID: P32754
• Chromosome Location: 12q14-qter
• Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Phenylalanine and tyrosine catabolism, organism-specific biosystem; Phenylalanine metabolism, organism-specific biosystem
• Function: 4-hydroxyphenylpyruvate dioxygenase activity; 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding