| Description : |
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. |
| Protein length : |
598 amino acids |
| Molecular Weight : |
91.780kDa inclusive of tags |
| Source : |
Wheat germ |
| Tissue specificity : |
Glomerulus of kidney. Also detected in brain, lung and placenta. |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNI VVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPP PVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEG KDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLVSEATF NKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNIS SGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPME YENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTT FSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVS VHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPP SDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRK YVVEMFYFNPATMTSEWTTYYEIAATVSLTASVVIFP |
| Sequence Similarities : |
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.Contains 8 fibronectin type-III domains.Contains 1 tyrosine-protein phosphatase domain. |
