Recombinant Human PTPRO Protein, His-tagged

• Cat.No.: PTPRO-2643H
• Product Overview: Recombinant Human PTPRO Protein (Phe938-Met1195) with a N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 33.9 kDa
  Accurate Molecular Mass: 36 kDa
• Protein length: Phe938-Met1195
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: PTPRO protein tyrosine phosphatase, receptor type, O [ Homo sapiens (human) ]
• Official Symbol: PTPRO
• Synonyms: PTPRO; protein tyrosine phosphatase, receptor type, O; receptor-type tyrosine-protein phosphatase O; GLEPP1; NPHS6; osteoclastic transmembrane protein tyrosine phosphatase; PTP oc; PTP U2; PTPU2; PTP phi; PTPase U2; phosphotyrosine phosphatase U2; glomerular epithelial protein 1; protein tyrosine phosphatase PTP-U2; osteoclastic transmembrane protein-tyrosine phosphatase; PTP-OC; PTP-U2; PTPROT; R-PTP-O
• Gene ID: 5800
• mRNA Refseq: NM_002848
• Protein Refseq: NP_002839
• MIM: 600579
• UniProt ID: Q16827