Recombinant Human NEDD4, FLAG-tagged NEDD4-520H

Cat. No. :	NEDD4-520H
Product Overview :	Recombinant Human NEDD4 (amino-acids 150-end) was expressed in aBaculovirus infected Sf9cell expression system with N-terminal FLAG tag, MW= 86 kDa.
Description :	E3 ubiquitin-protein ligase NEDD4 is an enzyme that in humans is encoded by the NEDD4 gene.
Source :	Sf9.
Formulated In :	25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 100 μg/ml FLAG peptide, 20% glycerol, and 3 mM DTT.
Application :	Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity :	> 60%.
Stability :	>6 months at -80°C.

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Gene Name :	NEDD4 neural precursor cell expressed, developmentally down-regulated 4 [ Homo sapiens ]
Synonyms :	neural precursor cell expressed, developmentally down-regulated 4; RPF1; NEDD4-1; KIAA0093; MGC176705; NEDD4; receptor-potentiating factor 1; EC 6.3.2.-; NEDD-4; Neural precursor cell expressed developmentally down-regulated protein 4
Gene ID :	4734
mRNA Refseq :	NM_006154
Protein Refseq :	NP_006145
MIM :	602278
UniProt ID :	P46934
Chromosome Location :	15q
Pathway :	Endocytosis; Ubiquitin mediated proteolysis
Function :	RNA polymerase binding; acid-amino acid ligase activity; beta-2 adrenergic receptor binding; ligase activity; phosphoserine binding; ubiquitin binding ; phosphothreonine binding; proline-rich region binding; protein domain specific binding; sodium channel inhibitor activity; ubiquitin-protein ligase activity