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NEDD4

  • Official Full Name

    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

  • Overview

    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.
  • Synonyms

    NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; RPF1; NEDD4-1; E3 ubiquitin-protein ligase NEDD4; receptor-potentiating factor 1; cell proliferation-inducing gene 53 protein; neural precursor cell expressed developmentally down-regulated protein 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • N/A
  • N
  • 6×His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEDD4-01H Active Recombinant Human NEDD4 protein, His-tagged E.coli His
Human NEDD4-29278TH Recombinant Human NEDD4, FLAG-tagged Insect Cell Flag 751 amino acids
Human NEDD4-520H Recombinant Human NEDD4, FLAG-tagged Sf9 Insect Cell Flag
Human NEDD4-1252H Recombinant Human NEDD4, GST-tagged E.coli GST C-350aa
Human NEDD4-3886HCL Recombinant Human NEDD4 293 Cell Lysate HEK293 N/A
Human NEDD4-1245H Recombinant Human NEDD4 protein, GST-tagged E.coli GST
Human NEDD4-14H Active Recombinant Human NEDD4 Protein (Leu570-Asp1319), N-6×His-tagged Insect Cell N-6×His Leu570-Asp1319
Human NEDD4-4676H Recombinant Human NEDD4 Protein (Met1-Asp900), N-GST tagged E.coli N-GST Met1-Asp900
Human NEDD4-2461H Recombinant Human NEDD4 protein, His-tagged E.coli His 970-1319 aa
Mouse Nedd4-4359M Recombinant Mouse Nedd4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

NEDD4 involved in several pathways and played different roles in them. We selected most pathways NEDD4 participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisFBXW11A;UBA3;CDC34A;CDC23;UBE2L3B;SIAH1A;HERC3;ANAPC11;UBE4B
EndocytosisEHD1B;MVB12BA;KIT;CCDC53;ARF3;GIT2A;NEDD4;RABEP1;PDCD6IP
Epstein-Barr virus infectionENTPD3;MAP3K14;EIF2AK1;TRAF3;POLR3H;TRAF1;SKP2;RELB;POLR3D

NEDD4 has several biochemical functions, for example, RNA polymerase binding, beta-2 adrenergic receptor binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD4 itself. We selected most functions NEDD4 had, and list some proteins which have the same functions with NEDD4. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase bindingBIN1;PPIB;PHRF1;STOM;PKN2;TAF10;YTHDC2;RRN3;WDHD1
beta-2 adrenergic receptor bindingNEDD4;BDKRB2;PDE4D;SLC9A3R1;GNAS
ligase activityRNF38;MARCH2;NEURL1B;C12orf51;TRIM23;RNF43;NEDD4;FPGS;RNF6
phosphoserine bindingNEDD4;YWHAB;PIN1;YWHAE
phosphothreonine bindingPIN1;NEDD4
proline-rich region bindingAPBB1;BAIAP2;CYLD;ITSN1;NEDD4;TCERG1;ABL1;GAREM;GHR
protein bindingFAM71C;SCG5;TCTN2;PTPN2;MID1IP1;VPS11;WHRN;CCT2;PER3
protein domain specific bindingTACC1;FOXA3;SNCA;CNTROB;NEDD4;CAPG;STX1A;STRN4;TBL1X
sodium channel inhibitor activityNEDD4L;SLC14A2;NEDD4;CAMK2D;SCN1B;PCSK9
ubiquitin bindingVPS36;D17WSU92E;TSG101;FAF1;FAM125A;PER2;OTUB1;UCHL3;USP5
ubiquitin protein ligase activityRNF126;TRIM24;MYLIP;MED23;MED7;NEDD4L;UBR2;CBLC;UBE2B

NEDD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD4.

SCNN1B; FGFR1

Research Area

Related articles

Huang, Z; Choi, BK; et al. The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling. ONCOGENE 34:1105-1115(2015).
Mujoo, K; Choi, BK; et al. Regulation of ERBB3/HER3 signaling in cancer. ONCOTARGET 5:10222-10236(2014).
  • Q&As
  • Reviews

Q&As (6)

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What is the role of the NEDD4 protein in tumorigenesis and progression? 04/09/2022

Studies have shown that NEDD4 protein plays an important role in the initiation and progression of certain tumors, for example, in gliomas, the expression level of NEDD4 protein is related to the degree of malignancy and prognosis of tumors.

What is the relationship between the NEDD4 protein and the immune system? 12/19/2021

NEDD4 protein can affect the function of the immune system, for example by regulating the degradation of specific receptors to affect the activation and differentiation of immune cells.

How well is the NEDD4 protein expressed in different tissues and organs? 08/09/2020

The expression of NEDD4 protein in different tissues and organs is different, and it is expressed in the nervous system, tumor tissue, and other organ tissues, and the expression level may be affected by many factors.

What is the relationship between NEDD4 protein and apoptosis? 07/28/2019

NEDD4 protein can influence the apoptosis process by regulating the degradation of specific receptors. For example, it can degrade the anti-apoptotic protein BCL-XL and promote apoptosis.

How does the NEDD4 protein affect signaling in neurons? 06/28/2019

The NEDD4 protein can affect the signaling of neurons by affecting the degradation of specific receptors within neurons, such as regulating G protein-coupled receptors (GPCRs) and serine/threonine kinase receptors.

How does the NEDD4 protein relate to other biomarkers? 03/25/2019

Studies have shown that there is an association between the expression level of the NEDD4 protein and certain biomarkers, for example, it can be used as a biomarker for predicting glioma prognosis.

Customer Reviews (3)

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Reviews
10/22/2021

    The stability of NEDD4 was still very good after prolonged storage or repeated use, indicating its high reliability and trustworthiness.

    10/15/2021

      This high band intensity of NEDD4 in Western blot improved the signal-to-noise ratio of the experiment.

      06/15/2019

        Beacuse reproducibility of NEDD4 is very good, and the results of each experiment are very consistent, indicating that its production process is very careful.

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