NEDD4
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Official Full Name
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
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Overview
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. -
Synonyms
NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; RPF1; NEDD4-1; E3 ubiquitin-protein ligase NEDD4; receptor-potentiating factor 1; cell proliferation-inducing gene 53 protein; neural precursor cell expressed developmentally down-regulated protein 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Sf9 Insect Cell
- Flag
- GST
- His
- Myc
- DDK
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NEDD4-01H | Active Recombinant Human NEDD4 protein, His-tagged | E.coli | His |
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| Human | NEDD4-29278TH | Recombinant Human NEDD4, FLAG-tagged | Insect Cell | Flag | 751 amino acids |
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| Human | NEDD4-520H | Recombinant Human NEDD4, FLAG-tagged | Sf9 Insect Cell | Flag | 150-end |
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| Human | NEDD4-1252H | Recombinant Human NEDD4, GST-tagged | E.coli | GST | C-350aa | |
| Human | NEDD4-3886HCL | Recombinant Human NEDD4 293 Cell Lysate | HEK293 | Non |
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| Human | NEDD4-1245H | Recombinant Human NEDD4 protein, GST-tagged | E.coli | GST |
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| Human | NEDD4-14H | Active Recombinant Human NEDD4 Protein (Leu570-Asp1319), N-6×His-tagged | Insect Cell | His | Leu570-Asp1319 |
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| Human | NEDD4-4676H | Recombinant Human NEDD4 Protein (Met1-Asp900), N-GST tagged | E.coli | GST | Met1-Asp900 |
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| Human | NEDD4-2461H | Recombinant Human NEDD4 protein, His-tagged | E.coli | His | 970-1319 aa | |
| Mouse | Nedd4-4359M | Recombinant Mouse Nedd4 Protein, Myc/DDK-tagged | HEK293T | Myc&DDK |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
NEDD4 involved in several pathways and played different roles in them. We selected most pathways NEDD4 participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | TRIP12;UBA6;UBE2QL1;BTRC;TRIM32;UBE2IB;UBA2;CUL4B;CUL1B |
| Endocytosis | ZFYVE20;TGFB1;IST1;RNF103-CHMP3;STAMBPA;RET;EHD1;RLN1;ARRB2A |
| Epstein-Barr virus infection | PSMD3;HDAC4;POLR3D;PLCG2;CD44;RELB;POLR3E;PSMD13;HSPA1A |
NEDD4 has several biochemical functions, for example, RNA polymerase binding, beta-2 adrenergic receptor binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD4 itself. We selected most functions NEDD4 had, and list some proteins which have the same functions with NEDD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase binding | STOM;PPIB;WDHD1;ANP32B;GSG1;PHRF1;YTHDC2;NEDD4;BIN1 |
| beta-2 adrenergic receptor binding | SLC9A3R1;NEDD4;PDE4D;BDKRB2;GNAS |
| ligase activity | MARCH5L;LRSAM1;TTC3;RNF133;TRIM24;TRIM27;MDM2;TRIM69;MIB1 |
| phosphoserine binding | YWHAE;NEDD4;PIN1;YWHAB |
| phosphothreonine binding | PIN1;NEDD4 |
| proline-rich region binding | YAP1;GAREM;PFN1;TCERG1;CSK;RABAC1;CYLD;ABL1;PRPF40A |
| protein binding | CLN3;PFKFB1;SLC8A1;DCDC2B;FAM113B;RBM6;INHBA;PARD3;TUBA3E |
| protein domain specific binding | IKBKG;CENPJ;WNT3A;POU2F2;HIST1H4I;VRK2;YWHABB;YWHAE1;Akap2 |
| sodium channel inhibitor activity | SCN1B;CAMK2D;NEDD4;PCSK9;NEDD4L;SLC14A2 |
| ubiquitin binding | D17WSU92E;CRY1;MARK4;TNFAIP3;NUP62;USP25;FAF1;KCNS1;FAF2 |
| ubiquitin protein ligase activity | MED7;TRIM37;MARCH1;TRAIP;MSL2B;C18orf25;LTN1;CBLL1;UBE2KA |
NEDD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD4.
SCNN1B; FGFR1
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe stability of NEDD4 was still very good after prolonged storage or repeated use, indicating its high reliability and trustworthiness.
This high band intensity of NEDD4 in Western blot improved the signal-to-noise ratio of the experiment.
Beacuse reproducibility of NEDD4 is very good, and the results of each experiment are very consistent, indicating that its production process is very careful.
Q&As (6)
Ask a questionStudies have shown that NEDD4 protein plays an important role in the initiation and progression of certain tumors, for example, in gliomas, the expression level of NEDD4 protein is related to the degree of malignancy and prognosis of tumors.
NEDD4 protein can affect the function of the immune system, for example by regulating the degradation of specific receptors to affect the activation and differentiation of immune cells.
The expression of NEDD4 protein in different tissues and organs is different, and it is expressed in the nervous system, tumor tissue, and other organ tissues, and the expression level may be affected by many factors.
NEDD4 protein can influence the apoptosis process by regulating the degradation of specific receptors. For example, it can degrade the anti-apoptotic protein BCL-XL and promote apoptosis.
The NEDD4 protein can affect the signaling of neurons by affecting the degradation of specific receptors within neurons, such as regulating G protein-coupled receptors (GPCRs) and serine/threonine kinase receptors.
Studies have shown that there is an association between the expression level of the NEDD4 protein and certain biomarkers, for example, it can be used as a biomarker for predicting glioma prognosis.
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